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Bodybuilding supplement
1,4,6-Androstatriene-3,17-dione
Другие языки:

    1,4,6-Androstatriene-3,17-dione

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    1,4,6-Androstatriene-3,17-dione
    1,4,6-androstatrien-3,17-dione.png
    Clinical data
    Routes of
    administration    		 Oral
    Legal status
    Legal status
    • US: Supplement
    Pharmacokinetic data
    Metabolism Hepatic
    Elimination half-life 48 hours
    Identifiers
    • (8R,9S,10R,13S,14S)-10,13-dimethyl-9,11,12,14,15,16-hexahydro-8H-cyclopenta[a]phenanthrene-3,17-dione
    CAS Number
    PubChem CID
    ChemSpider
    UNII
    ChEBI
    CompTox Dashboard (EPA)
    Chemical and physical data
    Formula C19H22O2
    Molar mass 282 g·mol−1
    3D model (JSmol)
    • O=C\4\C=C/[C@]3(C(/C=C\[C@H]2[C@H]1[C@@](C(=O)CC1)(CC[C@@H]23)C)=C/4)C
    • InChI=1S/C19H22O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3-4,7,9,11,14-16H,5-6,8,10H2,1-2H3/t14-,15-,16-,18-,19-/m0/s1 checkY
    • Key:DKVSUQWCZQBWCP-QAGGRKNESA-N checkY
      (verify)

    1,4,6-Androstatriene-3,17-dione (ATD) is a potent irreversible aromatase inhibitor that inhibits estrogen biosynthesis by permanently binding and inactivating aromatase in adipose and peripheral tissue. It is used to control estrogen synthesis.

    ATD was present in some over-the-counter bodybuilding supplements until 2009, as well as Topical ATD solutions that work transdermally. The product was developed and commercialized in the dietary supplement market place by industry journeyman Bruce Kneller, who holds a United States Patent for use of the compound and related compounds (#7,939,517) and Gaspari Nutrition. ATD has many names in sports supplements including: 1,4,6 etiollochan-dione, 3, 17-keto-etiochol-triene, androst-1,4,6-triene-3,17-dione and many others. These all refer to CAS# 633-35-2.

    ATD may cause a positive test for the anabolic steroid Boldenone, of which it is a possible metabolite and production contaminant. ATD is also prohibited in amateur and professional sports which forbids aromatase inhibitors.

    A related agent is exemestane (Aromasin).

    Further reading

    • Ellinwood WE, Hess DL, Roselli CE, Spies HG, Resko JA (1984). "Inhibition of aromatization stimulates luteinizing hormone and testosterone secretion in adult male rhesus monkeys". J. Clin. Endocrinol. Metab. 59 (6): 1088–96. doi:10.1210/jcem-59-6-1088. PMID 6541658.

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