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Norepinephrine–dopamine reuptake inhibitors
4'-Methyl-α-pyrrolidinohexiophenone
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    4'-Methyl-α-pyrrolidinohexiophenone

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    4'-Methyl-α-pyrrolidinohexiophenone
    MPHP.svg
    Clinical data
    Other names MPHP
    Legal status
    Legal status
    Identifiers
    • (RS)-1-(4-Methylphenyl)-2-(1-pyrrolidinyl)-1-hexanone
    CAS Number
    PubChem CID
    ChemSpider
    UNII
    Chemical and physical data
    Formula C17H25NO
    Molar mass 259.393 g·mol−1
    3D model (JSmol)
    Chirality Racemic mixture
    • c2cc(C)ccc2C(=O)C(CCCC)N1CCCC1
    • InChI=1S/C17H25NO/c1-3-4-7-16(18-12-5-6-13-18)17(19)15-10-8-14(2)9-11-15/h8-11,16H,3-7,12-13H2,1-2H3
    • Key:YOSQVMGMENUCDX-UHFFFAOYSA-N

    4'-Methyl-α-pyrrolidinohexiophenone (MPHP) is a stimulant compound which has been reported as a novel designer drug. It is closely related to pyrovalerone, being simply its chain-lengthened homologue. In the pyrrolidinophenone series, stimulant activity is maintained so long as the positions of the aryl, ketone and pyrrolidinyl groups are held constant, while the alkyl backbone can be varied anywhere between three and as many as seven carbons, with highest potency usually seen with the pentyl or isohexyl backbone, and a variety of substituents are tolerated on the aromatic ring.

    In 2010 a group of researchers from the Institute of Forensic Medicine, University Hospital Jena, Germany concluded that MPHP can lead to serious poisoning with toxic liver damage and rhabdomyolysis.

    Legality

    In the United States, MPHP is a Schedule I Controlled Substance. Sweden's public health agency suggested to classify MPHP as narcotic on June 1, 2015.

    See also


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