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Pharmacology stubs
5-Fluoro-MET
Другие языки:

    5-Fluoro-MET

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    5-Fluoro-MET
    5-F-MET.svg
    Clinical data
    Other names 5F-MET
    Identifiers
    • N-ethyl-2-(5-fluoro-1H-indol-3-yl)-N-methylethanamine
    PubChem CID
    Chemical and physical data
    Formula C13H17FN2
    Molar mass 220.291 g·mol−1
    3D model (JSmol)
    • CCN(C)CCC1=CNC2=C1C=C(C=C2)F
    • InChI=1S/C13H17FN2/c1-3-16(2)7-6-10-9-15-13-5-4-11(14)8-12(10)13/h4-5,8-9,15H,3,6-7H2,1-2H3
    • Key:XRWQULAXCLVBPP-UHFFFAOYSA-N

    5-Fluoro-MET (5F-MET, 5-fluoro-N-methyl-N-ethyltryptamine) is a psychedelic tryptamine derivative related to drugs such as 5-Fluoro-DMT and N-Methyl-N-ethyltryptamine (MET). It acts as an agonist at the 5-HT2A receptor with an EC50 of 20.6 nM and produces a head-twitch response in animal studies. Ring fluorination in this case increases efficacy at 5-HT2A, with 5F-MET having an efficacy of 87.6% vs 5-HT, vs 36.2% for the partial agonist MET. It is claimed to have antidepressant activity.

    See also



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