5-TFMO-DMT

5-(Trifluoromethoxy)-DMT

Clinical data
Other names	5-OCF3-DMT
Identifiers
IUPAC name N,N-dimethyl-5-(trifluoromethoxy)-1H-Indole-3-ethanamine
CAS Number	2857094-46-1 Y
PubChem CID	166116644
Chemical and physical data
Formula	C13H15F3N2O
Molar mass	272.271 g·mol−1
3D model (JSmol)	Interactive image
SMILES CN(C)CCC1=CNC2=CC=C(OC(F)(F)F)C=C21
InChI InChI=InChI=1S/C13H15F3N2O/c1-18(2)6-5-9-8-17-12-4-3-10(7-11(9)12)19-13(14,15)16/h3-4,7-8,17H,5-6H2,1-2H3 Key:ODQYGFDOWUZNBA-UHFFFAOYSA-N

5-TFMO-DMT (5-(trifluoromethoxy)-DMT, 5-OCF3-DMT, 5-(trifluoromethoxy)-N,N-dimethyltryptamine) is a psychedelic tryptamine derivative related to drugs such as 5-MeO-DMT and DMT (DMT). It acts as an agonist at the 5-HT_2A receptor with an EC₅₀ of 127.2 nM. It was shown to release serotonin (5-HT) from synaptosomal preparations, and to reduce immobility time in the forced-swim test in animal studies, suggesting that it might have antidepressant activity.

See also

• 5-MeO-DMT
• 5-EtO-DMT
• 5-Fluoro-DMT
• 5-TFM-DMT