7p22.1 microduplication syndrome
| 7p22.1 microduplication syndrome | |
|---|---|
| Other names | Trisomy 7p22.1 |
| Specialty | Medical genetics |
| Symptoms | intellectual disabilities, speech and motor delay, facial dysmorphisms |
| Usual onset | Birth |
| Duration | Life-long |
| Causes | Duplication of the p22.1 region in chromosome 7 |
7p22.1 microduplication syndrome (also called Trisomy 7p22.1) is a newly discovered genetic disorder which is characterized by cranial and facial dysmorphisms, intellectual disability, and motor-speech delays. It is caused by a duplication of the p22.1 region of chromosome 7.
Signs and symptoms
The symptoms of this syndrome are (but are not limited to) cranio-facial dysmorphisms such as macrocephaly, frontal bossing, low-set ears, hypertelorism, etc., intellectual disabilities, speech and motor delays, and heart, ocular, renal and skeletal defects (such as patent foramen ovale {heart} or brachydactyly type D {skeletal} ).
Causes
This condition (as the name implies) is caused by a 430 kB duplication of the p22.1 region of chromosome 7. This mutation is autosomal recessive, meaning that a baby would need 1 copy of a mutated gene from both parents in order to show symptoms of the disorder.
Epidemiology
Only 60 cases of 7q22.1 microduplication syndrome have been recorded in medical literature.