Abacavir/lamivudine/zidovudine

Abacavir/lamivudine/zidovudine

Combination of
Abacavir sulfate	Nucleoside analogue reverse transcriptase inhibitor
Lamivudine	Nucleoside analogue reverse transcriptase inhibitor
Zidovudine	Nucleoside analogue reverse transcriptase inhibitor
Clinical data
Trade names	Trizivir
AHFS/Drugs.com	Professional Drug Facts
MedlinePlus	a616051
License data	US DailyMed: Trizivir
Pregnancy category	AU: B3
Routes of administration	By mouth
ATC code	J05AR04 (WHO)
Legal status
Legal status	AU: S4 (Prescription only) CA: Schedule IV UK: POM (Prescription only) US: ℞-only EU: Rx-only In general: ℞ (Prescription only)
Identifiers
CAS Number	136470-78-5 N
PubChem CID	468908
ChemSpider	21106400 Y
KEGG	D10838 N
NIAID ChemDB	058986
NY (what is this?)  (verify)

Abacavir/lamivudine/zidovudine, sold under the brand name Trizivir, is a fixed-dose combination antiretroviral medication for the treatment of HIV/AIDS. It contains three reverse transcriptase inhibitors patented by GlaxoSmithKline and marketed by a joint venture with Pfizer, ViiV Healthcare:

• abacavir sulfate (ABC)
• lamivudine (3TC)
• zidovudine (AZT or ZDV)

It is indicated in the treatment of AIDS/HIV-1. For this purpose, the combination is very useful in pregnant women to decrease the risk of mother-to-child transmission.

The most common effects include headache and nausea (feeling sick).

Abacavir/lamivudine/zidovudine was approved for use in the United States and the European Union in 2000. In December 2013, Lupin Limited launched a generic version of abacavir/lamivudine/zidovudine.

Side effects

The most common side effects of abacavir/lamivudine/zidovudine include nausea, vomiting, diarrhea, fatigue, paresthesia and headache. As with many medications targeting reverse transcriptase, body fat redistribution syndrome may occur, causing body fat to center on the upper back and neck, breast, and torso, and potentially decreasing around the legs, arms, and face.IRIS may occur which is when the immune system initially improves, but then deteriorates as a previously ignored infection becomes active. Other serious side effects include:

• Increased risk of heart attack
• Lactic acidosis
• Severe hepatomegaly
• Lipoatrophy
• Neutropenia
• Anemia
• Hypersensitivity reactions
  • Includes liver failure, renal failure, anaphylaxis, hypotension, and death.

See also

• Abacavir/lamivudine
• Abacavir/dolutegravir/lamivudine

External links

• "Abacavir sulfate mixture with lamivudine and zidovudine". Drug Information Portal. U.S. National Library of Medicine.