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Drugs acting on the gastrointestinal system and metabolism
Aceglutamide
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Aceglutamide

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Aceglutamide
Stereo, skeletal formula of aceglutamide (S)
Names
Preferred IUPAC name
2-Acetamido-5-amino-5-oxopentanoic acid
Other names
2-(Acetylamino)-glutaramidic acid
α-N-Acetylglutamine;
Identifiers
3D model (JSmol)
ChemSpider
DrugBank
ECHA InfoCard 100.017.862
EC Number
  • 219-647-7
KEGG
MeSH aceglutamide
PubChem CID
UNII
  • InChI=1S/C7H12N2O4/c1-4(10)9-5(7(12)13)2-3-6(8)11/h5H,2-3H2,1H3,(H2,8,11)(H,9,10)(H,12,13) checkY
    Key: KSMRODHGGIIXDV-UHFFFAOYSA-N checkY
  • CC(=O)NC(CCC(N)=O)C(O)=O
Properties
C7H12N2O4
Molar mass 188.183 g·mol−1
Appearance White crystals
Melting point 197 °C (387 °F; 470 K)
Related compounds
Related alkanoic acids
Related compounds
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Aceglutamide (brand name Neuramina), or aceglutamide aluminium (brand name Glumal), also known as acetylglutamine, is a psychostimulant, nootropic, and antiulcer agent that is marketed in Spain and Japan. It is an acetylated form of the amino acid L-glutamine, the precursor of glutamate in the body and brain. Aceglutamide functions as a prodrug to glutamine with improved potency and stability.

Aceglutamide is used as a psychostimulant and nootropic, while aceglutamide aluminium is used in the treatment of ulcers. Aceglutamide can also be used as a liquid-stable source of glutamine to prevent damage from protein energy malnutrition. The drug has shown neuroprotective effects in an animal model of cerebral ischemia.

See also


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