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Arachidonyl-2'-chloroethylamide
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    Arachidonyl-2'-chloroethylamide

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    Arachidonyl-2'-chloroethylamide
    Arachidonyl-2-chloroethylamide.svg
    Names
    Preferred IUPAC name
    (5Z,8Z,11Z,14Z)-N-(2-Chloroethyl)icosa-5,8,11,14-tetraenamide
    Other names
    Arachidonyl-2'-chloroethylamide; ACEA
    Identifiers
    3D model (JSmol)
    ChEBI
    ChEMBL
    ChemSpider
    PubChem CID
    • InChI=1S/C22H36ClNO/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-22(25)24-21-20-23/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,24,25)/b7-6-,10-9-,13-12-,16-15- checkY
      Key: SCJNCDSAIRBRIA-DOFZRALJSA-N checkY
    • InChI=1/C22H36ClNO/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-22(25)24-21-20-23/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,24,25)/b7-6-,10-9-,13-12-,16-15-
      Key: SCJNCDSAIRBRIA-DOFZRALJBU
    • ClCCNC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC
    Properties
    C22H36ClNO
    Molar mass 365.99 g·mol−1
    Solubility in other solvents soluble in ethanol, chloroform, THF and DMSO
    Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
    ☒N (what is checkY☒N ?)

    Arachidonyl-2'-chloroethylamide (ACEA) is a synthetic agonist of the CB1 (CB1R). ACEA is considered to be a selective cannabinoid agonist as it binds primarily to the CB1R and has low affinity to the CB2 (CB2R) (Ki = 1.4 nM for CB1R; Ki = 3100 nM for CB2R).


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