Мы используем файлы cookie.
Продолжая использовать сайт, вы даете свое согласие на работу с этими файлами.
GSK plc brands
Atriance
Другие языки:

    Atriance

    Подписчиков: 0, рейтинг: 0
    Nelarabine
    Nelarabine structure.svg
    Nelarabine ball-and-stick.png
    Clinical data
    Trade names Arranon, Atriance
    Other names 506U78
    AHFS/Drugs.com Monograph
    MedlinePlus a607077
    License data
    Routes of
    administration    		 Intravenous
    ATC code
    Legal status
    Legal status
    Pharmacokinetic data
    Bioavailability n/a
    Protein binding <25%
    Metabolism By adenosine deaminase, to 9-β-D-arabinofuranosylguanine
    Elimination half-life 30 minutes (nelarabine)
    3 hours (ara-G)
    Excretion Kidney
    Identifiers
    CAS Number
    PubChem CID
    IUPHAR/BPS
    DrugBank
    ChemSpider
    UNII
    KEGG
    ChEMBL
    CompTox Dashboard (EPA)
    ECHA InfoCard 100.170.768
    Chemical and physical data
    Formula C11H15N5O5
    Molar mass 297.271 g·mol−1
    3D model (JSmol)
    • n2c1c(nc(nc1OC)N)n(c2)[C@@H]3O[C@@H]([C@@H](O)[C@@H]3O)CO
    • InChI=1S/C11H15N5O5/c1-20-9-5-8(14-11(12)15-9)16(3-13-5)10-7(19)6(18)4(2-17)21-10/h3-4,6-7,10,17-19H,2H2,1H3,(H2,12,14,15)/t4-,6-,7+,10-/m1/s1 checkY
    • Key:IXOXBSCIXZEQEQ-UHTZMRCNSA-N checkY
     ☒NcheckY (what is this?)  (verify)

    Nelarabine, sold under the brand names Arranon (US) and Atriance (EU), is a chemotherapy medication used for the treatment of T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL).

    Nelarabine is a prodrug of arabinosylguanine nucleotide triphosphate (araGTP), a type of purine nucleoside analog, which causes inhibition of DNA synthesis and cytotoxicity. Pre-clinical studies suggest that T-cells are particularly sensitive to nelarabine. In October 2005, it was approved by the FDA for acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma that has not responded to or has relapsed following treatment with at least two chemotherapy regimens. It was later approved in the European Union in October 2005. It is available as a generic medication.

    External links

    • "Nelarabine". Drug Information Portal. U.S. National Library of Medicine.
    • "Nelarabine". NCI Dictionary of Cancer Terms. National Cancer Institute.
    • "Nelarabine". National Cancer Institute.

    Новое сообщение