Cholecystokinin receptors or CCK receptors are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) and gastrin. There are two different subtypes CCKA and CCKB which are ~50% homologous: Various cholecystokinin antagonists have been developed and are used in research, although the only drug of this class that has been widely marketed to date is the anti-ulcer drug proglumide.
| Protein
|
Gene
|
Tissue distribution
|
Preferred ligand
|
Function
|
Mechanism
|
| CCKA (CCK1)
|
CCKAR
|
primarily gastrointestinal tract, lesser amounts in the CNS
|
sulfated CCK >> nonsulfated CCK ≈ nonsulfated CCK
|
stimulation of bicarb secretion, gall bladder emptying and inhibiting gut motility
|
Gq
|
| CCKB (CCK2)
|
CCKBR
|
primarily CNS, lesser amounts in the gastrointestinal tract
|
gastrin ≈ CCK (receptor does not discriminate between sulfated and nonsulfated peptides)
|
regulation of nociception, anxiety, memory and hunger
|
Gq/G11
|
External links
