Circular RNA databases and resources
In molecular biology, Circular RNAs (circRNAs) refer to a class of circular RNA molecules found across all kingdoms of life. Studies in 2013 have suggested that circRNAs play important regulatory roles in miRNA activity. Researchers found that CDR1as circRNA acts as a miR-7 super-sponge that contains about 70 target sites from the same miR-7 at the same transcript. The other testis-specific circRNA, sex-determining region Y (Sry), also was found as a miR-138 sponge. About-mentioned examples suggesting that miRNA sponge effects achieved by circRNA formation may be a general phenomenon. As miR-7 modulates the expression of several oncogenes, ciRS-7/miR-7 interactions may play an important roles in cancer-related pathways. circRNA has also been shown in viral infection where it sequesters anti-viral protein to enhance viral replication.
This Circular RNA (circRNA) databases and resources is a compilation of databases and web portals and servers used for circRNAs.
| Name | Description | type | References | |
|---|---|---|---|---|
| circRNABase | circRNABase is designed for decoding miRNA-circRNA interaction networks from thousands of circRNAs and 108 CLIP-Seq (HITS-CLIP, PAR-CLIP, iCLIP, CLASH) datasets. | database | ||
| circBase | circBase explore public circRNA datasets and download the custom python scripts needed to discover circRNAs in your own (ribominus) RNA-seq data. | database | ||
| CircNet | CircNet records public and novel circRNAs and putative circRNA-miRNA interactions. All the information is presented in an interactive user interface and available for download. | database | ||
| Circ2Traits | Circ2Traits a comprehensive database for circular RNA potentially associated with disease and traits. | database | ||
| Gokool et al. 2019 | The Landscape of Circular RNA Expression in the Human Brain | resource |