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Enzyme inhibitor
DAPT (chemical)
Другие языки:

    DAPT (chemical)

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    DAPT
    DAPT.svg
    Names
    Systematic IUPAC name
    tert-Butyl (S)-{(2S)-2-[2-(3,5-difluorophenyl)acetamido]propanamido}phenylacetate
    Other names
    gamma-Secretase Inhibitor IX; GSI-IX; LY-374973; N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester
    Identifiers
    3D model (JSmol)
    ChEBI
    ChEMBL
    ChemSpider
    PubChem CID
    • InChI=1S/C23H26F2N2O4/c1-14(26-19(28)12-15-10-17(24)13-18(25)11-15)21(29)27-20(16-8-6-5-7-9-16)22(30)31-23(2,3)4/h5-11,13-14,20H,12H2,1-4H3,(H,26,28)(H,27,29)/t14-,20-/m0/s1
      Key: DWJXYEABWRJFSP-XOBRGWDASA-N
    • C[C@@H](C(=O)N[C@@H](C1=CC=CC=C1)C(=O)OC(C)(C)C)NC(=O)CC2=CC(=CC(=C2)F)F
    Properties
    C23H26F2N2O4
    Molar mass 432.468 g·mol−1
    Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

    DAPT is a chemical compound used in the study of the Notch signaling pathway. DAPT is a γ-secretase inhibitor. It indirectly inhibits Notch, which is a substrate for γ-secretase.

    In a mouse model of Alzheimer's disease, DAPT reduces the levels of beta-amyloid.


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