Diminazene

Diminazene

Clinical data
Trade names	Azidin, Berenil, Ganasag, Pirocide
Other names	4,4'-(1-Triazene-1,3-diyl)bis(benzenecarboximidamide)
Routes of administration	IM, SC
ATCvet code	QP51AF01 (WHO) QP51AX07 (WHO)
Legal status
Legal status	Veterinary use only
Identifiers
IUPAC name 4-[2-(4-Carbamimidoylphenyl)iminohydrazinyl]benzenecarboximidamide
CAS Number	536-71-0 aceturate: 908-54-3
PubChem CID	2354
ChemSpider	2264
UNII	Y5G36EEA5Z aceturate: JI8SAD85NO
ChEBI	CHEBI:81724 Y
ChEMBL	ChEMBL124025 Y
CompTox Dashboard (EPA)	DTXSID7043792
ECHA InfoCard	100.007.860
Chemical and physical data
Formula	C14H15N7
Molar mass	281.323 g·mol−1
3D model (JSmol)	Interactive image
SMILES C1=CC(=CC=C1C(=N)N)N/N=N/C2=CC=C(C=C2)C(=N)N
InChI InChI=1S/C14H15N7/c15-13(16)9-1-5-11(6-2-9)19-21-20-12-7-3-10(4-8-12)14(17)18/h1-8H,(H3,15,16)(H3,17,18)(H,19,20) Key:XNYZHCFCZNMTFY-UHFFFAOYSA-N

Diminazene (INN; also known as diminazen) is an anti-infective medication for animals that is sold under a variety of brand names. It is effective against certain protozoa such as Babesia, Trypanosoma, and Cytauxzoon. The drug may also be effective against certain bacteria including Brucella and Streptococcus.

Chemically it is a di-amidine and it is formulated as its aceturate salt, diminazene aceturate.

The mechanism is not well understood; it probably inhibits DNA replication, but also has affinity to RNA.

Side effects

Acute side effects include vomiting, diarrhea, and hypotension (low blood pressure). Diminazen can harm the liver, kidneys and brain, which is potentially life-threatening; camels are especially susceptible to these effects.

Resistance

The Gibe River Valley in southwest Ethiopia showed universal resistance between July 1989 and February 1993. This likely indicates a permanent loss of function in this area against the tested target, T. congolense isolated from Boran cattle.