| Monoclonal antibody | |
|---|---|
| Type | Single-chain variable fragment |
| Source | Human |
| Target | fungal Hsp90 |
| Clinical data | |
| Trade names | Mycograb |
| Routes of administration |
Intravenous |
| ATC code |
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| Pharmacokinetic data | |
| Bioavailability | Not applicable (IV only) |
| Protein binding | High |
| Elimination half-life | 1–2 hours |
| Identifiers | |
| CAS Number | |
| ChemSpider |
|
| UNII | |
| KEGG | |
| Chemical and physical data | |
| Molar mass | Approximately 27.2 kg/mol |
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Efungumab (trade name Mycograb) was a drug developed by NeuTec Pharma (a subsidiary of Novartis), intended to treat candidemia (a bloodstream infection caused by pathogenic yeast) in combination with amphotericin B. The European Medicines Agency has twice refused to grant marketing authorization for Mycograb, citing product safety and quality issues.
Chemically, efungumab is a single-chain variable fragment of a human monoclonal antibody. As such, it "grabs" onto fungal hsp90, hence its proposed trade name.
Its ability to potentiate the effects of the antifungal amphotericin B in culture were later found to be non-specific.