Мы используем файлы cookie.
Продолжая использовать сайт, вы даете свое согласие на работу с этими файлами.
Epidemiology
Epidemiology data for low-linear energy transfer radiation
Другие языки:

    Epidemiology data for low-linear energy transfer radiation

    Подписчиков: 0, рейтинг: 0

    Epidemiological studies of the health effects of low levels of ionizing radiation, in particular the incidence and mortality from various forms of cancer, have been carried out in different population groups exposed to such radiation. These have included survivors of the atomic bombings of Hiroshima and Nagasaki in 1945, workers at nuclear reactors, and medical patients treated with X-rays.

    Life span studies of atomic bomb survivors

    Figure 1. From Preston et al.: Solid cancer dose-response function average over gender for attained age 70 after exposure at age 30. The solid straight-line is the linear slope estimate; the points are dose-category-specific ERR estimates; the dashed curve is a smoothed estimate that is derived from the points; and the dotted curves indicate upper and lower one-stand-error bounds on the smoothed estimate.

    Survivors of the atomic bomb explosions at Hiroshima and Nagasaki, Japan have been the subjects of a Life Span Study (LSS), which has provided valuable epidemiological data.

    The LSS population went through several changes:

    • 1945 – There were some 93,000 individuals, either living in Hiroshima or Nagasaki, Japan.
    • 1950 – An additional 37,000 were registered by this time, for a total of 130,000 LSS members.

    However, some 44,000 individuals were censured or excluded from the LSS project, so there remained about 86,000 people who were followed through the study. There is a gap in knowledge of the earliest cancer that developed in the first few years after the war, which impacts the assessment of leukemia to an important extent and for solid cancers to a minor extent. Table 1 shows summary statistics of the number of persons and deaths for different dose groups. These comparisons show that the doses that were received by the LSS population overlap strongly with the doses that are of concern to NASA Exploration mission (i.e., 50 to 2,000 milliSieverts (mSv)).

    Table 1. Number of persons, Cancer Deaths, and Non-cancer Deaths for Different Dose Groups in the Life Span Study
    DS86 Weighted Colon Dose, mSv
    Total 0-50 50-100 100-200 200-500 500-1,000 1,000-2,000 >2,000
    No. Subjects 86,572 37,458 31,650 5,732 6,332 3,299 1,613 488
    Cancer Deaths 9,335 3,833 3,277 668 763 438 274 82
    Non-cancer Deaths 31,881 13,832 11,633 2,163 2,423 1,161 506 163

    Figure 1 shows the dose response for the excess relative risk (ERR) for all solid cancers from Preston et al. Tables 2 and 3 show several summary parameters for tissue-specific cancer mortality risks for females and males, respectively, including estimates of ERR, excess absolute risk (EAR), and percentage attributable risks. Cancer incidence risks from low-LET radiation are about 60% higher than cancer mortality risks.

    Table 2. From Preston et al.: Tissue-specific Cancer Mortality Risk Summary Statistics (i.e., ERR, EAR, and Attributable Risks) for Females and Males, Respectively LSS Female Site-specific Summary Mortality Rate Estimates: Solid Cancers 1950-1997
    Site/System Deaths
    (>0.005Sv)     		ERR/Sva
    (90% CI)     		EAR/104PYb -Svc
    (90%CI)     		Attributable
    risk (%)d
    All solid cancer 4,884 (2,948) 0.63 (0.49; 0.79) 13.5 (7.4; 16.3) 9.2 (7.4; 11.0)
    Oral cavity 42 (25) -0.20 (<-0.3; 0.75) -0.04 (<-0.3; 0.14) -4.1 (<-6; 14)
    Digestive System
    Esophagus 67 (44) 1.7 (0.46; 3.8) 0.51 (0.15; 0.92) 22 (6.6; 42)
    Stomach 1,312 (786) 0.65 (0.40; 0.95) 3.3 (2.1; 4.7) 8.8 (5.5; 12)
    Colon 272 (786) 0.49 (0.11; 1.1) 0.68 (0.76; 1.3) 9.0 (4.3; 17)
    Rectum 198 (127) 0.75 (0.16; 1.6) 0.69 (0.16; 1.3) 11.3 (2.6; 22)
    Liver 514 (291) 0.35 (0.07; 0.72) 0.85 (0.18; 1.6) 6.2 (1.3; 12)
    Gallbladder 236 (149) 0.16 (-0.17; 0.67) 0.18 (-0.21; 0.71) 2.6 (-2.9; 10)
    Pancreas 244 (135) -0.01 (-0.28; 0.45) -0.01 (-0.35; 0.52) -0.2 (-5.0; 7.6)
    Respiratory System
    Lung 548 (348) 1.1 (0.678; 1.6) 2.5 (1.6; 3.5) 16 (10; 22)
    Female breast 272; (173) 0.79 (0.29; 1.5) 1.6 (1.2; 2.2) 24 (18; 32)
    Uterus 518 (323) 0.17 (-0.10; 0.52) 0.44 (-0.27; 1.3) 2.7 (-1.6; 7.9)
    Ovary 136 (85) 0.94 (0.07; 2.0) 0.63 (0.23; 1.2) 15 (5.3; 28)
    Urinary System
    Bladder 67 (43) 1.2 (0.10; 3.1) 0.33 (0.02; 0.74) 16 (0.9; 36)
    Kidney 31 (21) 0.97 (<-0.3; 3.8) 0.14 (<-0.1; 0.42) 14 (<-3; 42)
    Brain/CNSd 17 (10) 0.51 (<-0.3; 3.9) 0.04 (<-0.02; 0.2) 11 (<0.05; 57)
    aERR/SV for age at exposure 30 in an age-constant linear ERR model; bExcess absolute risk per 10,000 persons per year; cAverage EAR computed from ERR model; dAttributable risk among survivors whose estimated dose is at least 0.005 Sv; CNS – central nervous system.
    Table 3. From Preston et al.: Tissue-specific Cancer Mortality Risk Summary Statistics 9 i.e., ERR, EAR, and Attributable Risks) for Males LSS Male Site-specific Summary Mortality Rate Estimates: Solid Cancers 1950-1997
    Site/System Deaths
    (>0.005Sv)     		ERR/Sva
    (90% CI)     		EAR/104PYb -Svc
    (90%CI)     		Attributable
    risk (%)d
    All solid cancer 4,451 (2,554) 0.37 (0.26; 0.49) .6 (9.4; 16.2) 6.6 (4.9; 8.4)
    Oral cavity 68 (37) -0.20 (<-0.3; 0.45) -0.12 (<-0.3; 0.25) -5.2 (<-6; 11)
    Digestive System
    Esophagus 224 (130) 0.61 (0.15; 1.2) 1.1 (0.28; 2.0) 11.1 (2.8; 21)
    Stomach 1,555 (899) 0.20 (0.04; 0.39) 2.1 (0.43; 4.0) 3.2 (0.07; 6.2)
    Colon 206 (122) 0.54 (0.13; 1.2) 1.1 (0.64; 1.9) 12 (6.9; 21)
    Rectum 172 (96) -0.25 (<-0.3; 0.15) -0.41 (<-0.4; 0.22) -5.4 (<-6; 3.1)
    Liver 722 (408) 0.59 (0.11; 0.68) 2.4 (1.2; 4.0) 8.4 (4.2; 14)
    Gallbladder 92 (52) 0.89 (0.22; 1.9) 0.63 (0.17; 1.2) 17 (4.5; 33)
    Pancreas 163 (103) -0.11 (<-0.3; 0.44) -0.15 (<-0.4; 0.58) --1.9 (<-6; 7.5)
    Respiratory System
    Lung 716 (406) 0.48 (0.23; 0.78) 2.7 (1.4; 4.1) 9.7 (4.9; 15)
    Urinary System
    Bladder 82 (56) 1.1 (0.2; 2.5) 0.7 (0.1; 1.4) 17 (3.3; 34)
    Kidney 36 (18) -0.02 (<-0.3; 1.1) -0.01 (-0.1; 0.28) -0.4 (<-5; 22)
    Brain/CNSd 14 (9) 5.3 (1.4; 16) 0.35 (0.13; 0.59) 62 (23; 100)
    aERR/SV for age at exposure 30 in an age-constant linear ERR model; bExcess absolute risk per 10,000 persons per year; cAverage EAR computed from ERR model; dAttributable risk among survivors whose estimated dose is at least 0.005 Sv; CNS – central nervous system.

    Other human studies

    The BEIR VII Report contains an extensive review of data sets from human populations, including nuclear reactor workers and patients who were treated with radiation. The recent report from Cardis et al. describes a meta-analysis for reactor workers from several countries. A meta-analysis at specific cancer sites, including breast, lung, and leukemia, has also been performed. These studies require adjustments for photon energy, dose-rate, and country of origin as well as adjustments made in single population studies. Table 4 shows the results that are derived from Preston et al. for a meta-analysis of breast cancer risks in eight populations, including the atomic-bomb survivors. The median ERR varies by slightly more than a factor of two, but confidence levels significantly overlap. Adjustments for photon energy or dose-rate and fractionation have not been made. These types of analysis lend confidence to risk assessments as well as showing the limitations of such data sets.

    Of special interest to NASA is the dependence on age at exposure of low-LET cancer risk projections. The BEIR VII report prefers models that show less than a 25% reduction in risk over the range from 35 to 55 years, while NCRP Report No. 132 shows about a two-fold reduction over this range.

    Table 4. Results from Meta-analysis of Breast Cancer from Eight Population Groups, Including the Life Span Study of Atomic Bomb Survivors and Several Medical Patient Groups Exposed to X Rays, as described in Preston et al. Summary of Parameter Estimates for the Final Pooled ERR Model
    Cohort Reference age for
    the ERR/Gy estimate     		ERR/Gya Percentage change
    per decade increase
    in age at exposure     		Exponent of
    attained age     		Background
    SIRb
    LSS attained age 50 2.10
    (1.6; 2.8)     		Not includedb -2.0
    (-2.8; -1.1)     		1.01
    (0.9; 1.1)
    TBO attained age 50 0.74
    (0.4; 1.2)     		Not included -2.0
    (-2.8; -1.1)     		0.96
    (0.7; 1.2)
    TBX attained age 50 0.74
    (0.4; 1.2)     		Not included -2.0
    (-2.8; -1.1)     		0.73
    (0.6; 0.9)
    THY attained age 50 0.74
    (0.4; 1.2)     		Not included -2.0
    (-2.8; -1.1)     		1.05
    (0.7; 1.5)
    BBD age at exposure 25 1.9
    (1.3; 2.8)     		-60%
    (-71%; -44%)     		Not includedc 0.98
    (0.8; 1.2)
    APM all ages 0.56
    (0.3; 0.9)     		Not included Not included 1.45
    (1.1; 1.8)
    HMG all ages 0.34
    (0.1; 0.7)     		Not included Not included 1.07
    (0.8; 1.3)
    HMS all ages 0.34
    (0.1; 0.7)     		Not included Not included 1.05
    (0.9; 1.2)
    a C.I.'s within parentheses; bSIR = standardized incidence ratio; c"Not included" means that the risk is assumed not to vary with age at exposure (attained age).

    See also

    Public Domain This article incorporates public domain material from Human Health and Performance Risks of Space Exploration Missions (PDF). National Aeronautics and Space Administration. (NASA SP-2009-3405, pp. 132-134).


    Новое сообщение