| Erythema multiforme majus | |
|---|---|
| Other names | Erythema multiforme majus |
 | |
| Micrograph of confluent epidermal necrosis. H&E stain. | |
| Specialty | Dermatology |
Erythema multiforme major is a form of rash with skin loss or epidermal detachment.
The term "erythema multiforme majus" is sometimes used to imply a bullous (blistering) presentation.
According to some sources, there are two conditions included on a spectrum of this same disease process:
- Stevens–Johnson syndrome (SJS)
- Toxic epidermal necrolysis (TEN) which described by Alan Lyell and previously called Lyell syndrome[5].
In this view, EM major, SJS and TEN are considered a single condition, distinguished by degree of epidermal detachment.
However, a consensus classification separates erythema multiforme minor, erythema multiforme major, and SJS/TEN as three separate entities.
5. Orphanet Journal of Rare Diseases 2010, 5:39 doi:10.1186/1750-1172-5-39