Ethyl lauroyl arginate

Ethyl lauroyl arginate

Names
IUPAC name Ethyl (2S)-5-(diaminomethylideneamino)-2-(dodecanoylamino)pentanoate
Other names Ethyl Nα-lauroyl-L-arginate Lauric arginate ethyl ester
Identifiers
CAS Number	48076-74-0
3D model (JSmol)	Interactive image
ChemSpider	163603
E number	E243 (preservatives)
PubChem CID	188214
UNII	E0K8J7A41B
CompTox Dashboard (EPA)	DTXSID60893076
InChI InChI=1S/C20H40N4O3/c1-3-5-6-7-8-9-10-11-12-15-18(25)24-17(19(26)27-4-2)14-13-16-23-20(21)22/h17H,3-16H2,1-2H3,(H,24,25)(H4,21,22,23)/t17-/m0/s1 Key: XJTMYVOVQZMMKX-KRWDZBQOSA-N
SMILES CCCCCCCCCCCC(=O)NC(CCCN=C(N)N)C(=O)OCC
Properties
Chemical formula	C20H40N4O3
Molar mass	384.565 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Ethyl lauroyl arginate (LAE) is a food preservative more commonly known as E243.

It has chemical formula C₂₀H₄₀N₄O₃ and is a drug for dermatological disorders.

Periodontal diseases

LAE has potential in treating gingivitis, and the more advanced periodontitis. In a study comparing ethyl lauroyl arginate in 0.147% mouthwash to chlorhexidine 0.12% as an adjunctive therapy in the non-surgical treatment of periodontitis, the results showed there were no treatment-related adverse events. Total bacterial count and the specific pathogens were reduced at 4 weeks and 3 months by both mouthwashes with no statistical differences between them at neither periods of time. It was concluded that 0.147% LAE-containing mouthwash could be an alternative to the use of 0.12% chlorhexidine in the non-surgical therapy of periodontitis considering the similar clinical effects, more stable microbiological improvement and absence of adverse effects.

It is sold as the main active ingredient in Listerine Advanced Defence Gum Treatment and as one of the active ingredients in GUM Activital Mouthwash.