Мы используем файлы cookie.
Продолжая использовать сайт, вы даете свое согласие на работу с этими файлами.
Eurax
Другие языки:

    Eurax

    Подписчиков: 0, рейтинг: 0
    Crotamiton
    Crotamiton Structure V.svg
    Clinical data
    AHFS/Drugs.com Monograph
    ATCvet code
    Identifiers
    • (E)-N-Ethyl-N-(2-methylphenyl)but-2-enamide
    CAS Number
    PubChem CID
    DrugBank
    ChemSpider
    UNII
    KEGG
    ChEMBL
    CompTox Dashboard (EPA)
    ECHA InfoCard 100.006.907
    Chemical and physical data
    Formula C13H17NO
    Molar mass 203.285 g·mol−1
    3D model (JSmol)
    • O=C(N(c1ccccc1C)CC)/C=C/C
    • InChI=1S/C13H17NO/c1-4-8-13(15)14(5-2)12-10-7-6-9-11(12)3/h4,6-10H,5H2,1-3H3/b8-4+ checkY
    • Key:DNTGGZPQPQTDQF-XBXARRHUSA-N checkY
     ☒NcheckY (what is this?)  (verify)

    Crotamiton is a drug that is used both as a scabicidal (for treating scabies) and as a general antipruritic (anti-itching drug). It is a prescription, lotion-based medicine that is applied to the whole body to get rid of the scabies parasite that burrows under the skin and causes itching.

    Use

    For treating scabies, crotamiton should be applied to the whole body rather than a localized area. It is applied two or three times, with a 24-hour delay between applications, and the patient is asked to take a shower no sooner than after 48 hours. For children under 3 years, it is applied once daily. It can also be used to treat itching stemming from other causes, e.g. insect bites, in which case it is applied to the itching areas only, and repeated if necessary after 4 to 8 hours. Use near the eyes, or breaks in the skin, should be avoided.

    Pharmacology

    Crotamiton is toxic to the scabies mite. It probably acts as a general antipruritic by inhibition of TRPV4, a sensory ion channel that is expressed in the skin and primary sensory neurons.

    Pharmacokinetics

    After topical application, crotamiton is absorbed systemically. It has an elimination half-life of 30.9 hours and 4.8-8.8% is excreted in the urine.

    Side effects

    The most common side effect of crotamiton is skin irritation.

    Trade name

    Crotamiton is marketed under the trade names Eurax, which is manufactured by Ranbaxy Laboratories in the United States, and GlaxoSmithKline in the United Kingdom, and Euracin, which is manufactured by Green Cross in South Korea. In Germany, it is marketed under the brand name Crotamitex. In India, it is sold as Eurax by Ranbaxy Laboratories.


    Новое сообщение