High affinity immunoglobulin gamma Fc receptor I is a protein that in humans is encoded by the FCGR1A gene.
Interactions
The FcgRI binds the Fc portion of IgG and causes activation of the host cell via an intercellular ITAM motif.
Further reading
- Monteiro RC, Van De Winkel JG (2003). "IgA Fc receptors". Annual Review of Immunology. 21: 177–204. doi:10.1146/annurev.immunol.21.120601.141011. PMID 12524384.
- Ernst LK, van de Winkel JG, Chiu IM, Anderson CL (Aug 1992). "Three genes for the human high affinity Fc receptor for IgG (Fc gamma RI) encode four distinct transcription products". The Journal of Biological Chemistry. 267 (22): 15692–700. doi:10.1016/S0021-9258(19)49591-4. PMID 1379234.
- Benech PD, Sastry K, Iyer RR, Eichbaum QG, Raveh DP, Ezekowitz RA (Oct 1992). "Definition of interferon gamma-response elements in a novel human Fc gamma receptor gene (Fc gamma RIb) and characterization of the gene structure". The Journal of Experimental Medicine. 176 (4): 1115–23. doi:10.1084/jem.176.4.1115. PMC 2119393. PMID 1402657.
- Porges AJ, Redecha PB, Doebele R, Pan LC, Salmon JE, Kimberly RP (Nov 1992). "Novel Fc gamma receptor I family gene products in human mononuclear cells". The Journal of Clinical Investigation. 90 (5): 2102–9. doi:10.1172/JCI116094. PMC 443278. PMID 1430234.
- van de Winkel JG, Ernst LK, Anderson CL, Chiu IM (Jul 1991). "Gene organization of the human high affinity receptor for IgG, Fc gamma RI (CD64). Characterization and evidence for a second gene". The Journal of Biological Chemistry. 266 (20): 13449–55. doi:10.1016/S0021-9258(18)98860-5. PMID 1830050.
- Eizuru Y, Minamishima Y (1989). "Induction of Fc (IgG) receptor(s) by simian cytomegaloviruses in human embryonic lung fibroblasts". Intervirology. 29 (6): 339–45. doi:10.1159/000150065. PMID 2852656.
- Allen JM, Seed B (Jan 1989). "Isolation and expression of functional high-affinity Fc receptor complementary DNAs". Science. 243 (4889): 378–81. Bibcode:1989Sci...243..378A. doi:10.1126/science.2911749. PMID 2911749.
- Allen JM, Seed B (Dec 1988). "Nucleotide sequence of three cDNAs for the human high affinity Fc receptor (FcRI)". Nucleic Acids Research. 16 (24): 11824. doi:10.1093/nar/16.24.11824. PMC 339124. PMID 2974947.
- Indik ZK, Hunter S, Huang MM, Pan XQ, Chien P, Kelly C, Levinson AI, Kimberly RP, Schreiber AD (Jul 1994). "The high affinity Fc gamma receptor (CD64) induces phagocytosis in the absence of its cytoplasmic domain: the gamma subunit of Fc gamma RIIIA imparts phagocytic function to Fc gamma RI". Experimental Hematology. 22 (7): 599–606. PMID 7516890.
- Valerius T, Repp R, de Wit TP, Berthold S, Platzer E, Kalden JR, Gramatzki M, van de Winkel JG (Aug 1993). "Involvement of the high-affinity receptor for IgG (Fc gamma RI; CD64) in enhanced tumor cell cytotoxicity of neutrophils during granulocyte colony-stimulating factor therapy". Blood. 82 (3): 931–9. doi:10.1182/blood.V82.3.931.931. PMID 7687898.
- Wang AV, Scholl PR, Geha RS (Sep 1994). "Physical and functional association of the high affinity immunoglobulin G receptor (Fc gamma RI) with the kinases Hck and Lyn". The Journal of Experimental Medicine. 180 (3): 1165–70. doi:10.1084/jem.180.3.1165. PMC 2191633. PMID 8064233.
- Takai S, Kasama M, Yamada K, Kai N, Hirayama N, Namiki H, Taniyama T (Jan 1994). "Human high-affinity Fc gamma RI (CD64) gene mapped to chromosome 1q21.2-q21.3 by fluorescence in situ hybridization". Human Genetics. 93 (1): 13–5. doi:10.1007/BF00218905. PMID 8270248. S2CID 24623391.
- Morton HC, van den Herik-Oudijk IE, Vossebeld P, Snijders A, Verhoeven AJ, Capel PJ, van de Winkel JG (Dec 1995). "Functional association between the human myeloid immunoglobulin A Fc receptor (CD89) and FcR gamma chain. Molecular basis for CD89/FcR gamma chain association". The Journal of Biological Chemistry. 270 (50): 29781–7. doi:10.1074/jbc.270.50.29781. PMID 8530370.
- De SK, Venkateshan CN, Seth P, Gajdusek DC, Gibbs CJ (Mar 1998). "Adenovirus-mediated human immunodeficiency virus-1 Nef expression in human monocytes/macrophages and effect of Nef on downmodulation of Fcgamma receptors and expression of monokines". Blood. 91 (6): 2108–17. doi:10.1182/blood.V91.6.2108. PMID 9490697.
- Kyono WT, de Jong R, Park RK, Liu Y, Heisterkamp N, Groffen J, Durden DL (Nov 1998). "Differential interaction of Crkl with Cbl or C3G, Hef-1, and gamma subunit immunoreceptor tyrosine-based activation motif in signaling of myeloid high affinity Fc receptor for IgG (Fc gamma RI)". Journal of Immunology. 161 (10): 5555–63. PMID 9820532.
- Fanger NA, Cosman D, Peterson L, Braddy SC, Maliszewski CR, Borges L (Nov 1998). "The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes". European Journal of Immunology. 28 (11): 3423–34. doi:10.1002/(SICI)1521-4141(199811)28:11<3423::AID-IMMU3423>3.0.CO;2-2. PMID 9842885.
- Gorgani NN, Altin JG, Parish CR (Aug 1999). "Histidine-rich glycoprotein regulates the binding of monomeric IgG and immune complexes to monocytes". International Immunology. 11 (8): 1275–82. doi:10.1093/intimm/11.8.1275. PMID 10421785.
- Tridandapani S, Lyden TW, Smith JL, Carter JE, Coggeshall KM, Anderson CL (Jul 2000). "The adapter protein LAT enhances fcgamma receptor-mediated signal transduction in myeloid cells". The Journal of Biological Chemistry. 275 (27): 20480–7. doi:10.1074/jbc.M909462199. PMID 10781611.
External links
- Overview of all the structural information available in the PDB for UniProt: P12314 (Human High affinity immunoglobulin gamma Fc receptor I (FCGR1A)) at the PDBe-KB.