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Ferroquine

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Ferroquine

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Ferroquine
Identifiers

IUPAC name 7-chloro-N-(2-((dimethylamino)methyl)ferrocenyl)quinolin-4-amine
CAS Number	185055-67-8
PubChem CID	140118553
CompTox Dashboard (EPA)	DTXSID00939922
ECHA InfoCard	100.208.008
Chemical and physical data
Formula	C₂₃H₂₄ClFeN₃
Molar mass	433.76 g·mol⁻¹
InChI InChI=1S/C18H19ClN3.C5H5.Fe/c1-22(2)12-14-5-3-4-13(14)11-21-17-8-9-20-18-10-15(19)6-7-16(17)18;1-2-4-5-3-1;/h3-10H,11-12H2,1-2H3,(H,20,21);1-5H;/q2*-1;+2 Key:DDENDDKMBDTHAX-UHFFFAOYSA-N

Ferroquine is a synthetic compound related to chloroquine which acts as an antimalarial, and shows good activity against chloroquine-resistant strains. It contains an organometallic ferrocene ring which is unusual in pharmaceuticals, and while it was first reported in 1997, it has progressed slowly through clinical trials, with results from Phase II trials showing reasonable safety and efficacy, and further trials ongoing.