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Enzyme inhibitor
Fumarranol
Другие языки:

    Fumarranol

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    Fumarranol
    Fumarranol structure.png
    Identifiers
    • (1S,5S)-5-(hydroxymethyl)-1-methoxy-6-[(2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]bicyclo[3.1.0]hexan-2-one
    CAS Number
    PubChem CID
    Chemical and physical data
    Formula C16H24O4
    Molar mass 280.364 g·mol−1
    3D model (JSmol)
    • CC(=CC[C@@H]1[C@@](O1)(C)C2[C@]3([C@@]2(C(=O)CC3)OC)CO)C
    • InChI=1S/C16H24O4/c1-10(2)5-6-12-14(3,20-12)13-15(9-17)8-7-11(18)16(13,15)19-4/h5,12-13,17H,6-9H2,1-4H3/t12-,13?,14+,15-,16+/m1/s1
    • Key:CANZHCRPLGNWCR-LMINUHAASA-N

    Fumarranol is a drug which acts as an inhibitor of the type 2 methionine aminopeptidase enzyme METAP2. It was derived by structural modification of the natural product fumagillin. It was originally developed as an anti-angiogenesis drug for the treatment of cancer, but it was subsequently found to bind with high affinity to the METAP2 enzyme in malaria parasites and has been investigated as a potential treatment for malaria.

    See also


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