Integrin alpha-3 is a protein that in humans is encoded by the ITGA3 gene. ITGA3 is an integrin alpha subunit. Together with beta-1 subunit, it makes up half of the α3β1 integrin duplex that plays a role in neural migration and corticogenesis, acted upon by such factors as netrin-1 and reelin.
ITGA3 encodes the integrin alpha 3 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 3 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form an integrin that interacts with many extracellular matrix proteins.
Alternative names
The alpha 3 beta 1 integrin is known variously as: very late (activation) antigen 3 ('VLA-3'), very common antigen 2 ('VCA-2'), extracellular matrix receptor 1 ('ECMR1'), and galactoprotein b3 ('GAPB3').
Interactions
CD49c has been shown to interact with:
Further reading
- Bosman FT (1993). "Integrins: cell adhesives and modulators of cell function". Histochem. J. 25 (7): 469–77. doi:10.1007/BF00159282. PMID 8407358. S2CID 19661102.
- Fornaro M, Languino LR (1998). "Alternatively spliced variants: a new view of the integrin cytoplasmic domain". Matrix Biol. 16 (4): 185–93. doi:10.1016/S0945-053X(97)90007-X. PMID 9402008.
External links
- CD49c+antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- ITGA3 Info with links in the Cell Migration Gateway Archived 2014-12-11 at the Wayback Machine
- Human ITGA3 genome location and ITGA3 gene details page in the UCSC Genome Browser.