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CB1 receptor agonists
JWH-120
Другие языки:

    JWH-120

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    JWH-120
    JWH-120.png
    Legal status
    Legal status
    Identifiers
    • (4-Methyl-1-naphthalenyl)(1-propyl-1H-indol-3-yl)methanone
    CAS Number
    PubChem CID
    ChemSpider
    UNII
    ChEMBL
    CompTox Dashboard (EPA)
    Chemical and physical data
    Formula C23H21NO
    Molar mass 327.427 g·mol−1
    3D model (JSmol)
    • CCCN1C=C(C2=CC=CC=C21)C(=O)C3=CC=C(C4=CC=CC=C43)C
    • InChI=1S/C23H21NO/c1-3-14-24-15-21(19-10-6-7-11-22(19)24)23(25)20-13-12-16(2)17-8-4-5-9-18(17)20/h4-13,15H,3,14H2,1-2H3
    • Key:DUBUGSKBMMXSOU-UHFFFAOYSA-N

    JWH-120 is a synthetic cannabimimetic that was discovered by John W. Huffman. It is the N-propyl analog of JWH-122. It is a potent and selective ligand for the CB2 receptor, but a weaker ligand for the CB1 receptor. It has a binding affinity of Ki = 6.1 ± 0.7 nM at the CB2 subtype and 173 times selectivity over the CB1 subtype.

    In the United States, all CB1 receptor agonists of the 3-(1-naphthoyl)indole class such as JWH-120 are Schedule I Controlled Substances.

    See also


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