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CB1 receptor agonists
JWH-146
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    JWH-146

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    JWH-146
    JWH-146.svg
    Legal status
    Legal status
    Identifiers
    • (1-heptyl-5-phenyl-1H-pyrrol-3-yl)-1-naphthalenyl-methanone
    CAS Number
    PubChem CID
    ChemSpider
    UNII
    ChEMBL
    Chemical and physical data
    Formula C28H29NO
    Molar mass 395.546 g·mol−1
    3D model (JSmol)
    • O=C(C1=CC=CC2=C1C=CC=C2)C3=CN(CCCCCCC)C(C4=CC=CC=C4)=C3
    • InChI=1S/C28H29NO/c1-2-3-4-5-11-19-29-21-24(20-27(29)23-14-7-6-8-15-23)28(30)26-18-12-16-22-13-9-10-17-25(22)26/h6-10,12-18,20-21H,2-5,11,19H2,1H3 checkY
    • Key:JDBFNFBWXVCTSA-UHFFFAOYSA-N checkY

    JWH-146 (1-heptyl-5-phenyl-1H-pyrrol-3-yl)-1-naphthalenyl-methanone) is a synthetic cannabinoid from the naphthoylpyrrole family which acts as an agonist of the CB1 (Ki = 21 ± 2nM) and CB2 (Ki = 62 ± 5nM) receptors, with a moderate (~2.9x) selectivity for the CB1 receptor over the CB2 receptor. JWH-146 was first synthesized in 2006 by John W. Huffman and colleagues to examine the nature of ligand binding to the CB1 receptor.

    Legality

    In the United States JWH-146 is not federally scheduled, although some states have passed legislation banning the sale, possession, and manufacture of JWH-146.

    In Canada, JWH-146 and other naphthoylpyrrole-based cannabinoids are Schedule II controlled substances under the Controlled Drugs and Substances Act.

    In the United Kingdom, JWH-146 and other naphthoylpyrrole-based cannabinoids are considered Class B drugs under the Misuse of Drugs Act 1971.

    See also



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