JWH-368

JWH-368

Legal status
Legal status	CA: Schedule II UK: Class B
Identifiers
IUPAC name [5-(3-Fluorophenyl)-1-pentylpyrrol-3-yl]-naphthalen-1-ylmethanone
CAS Number	914458-31-4 Y
PubChem CID	44418331
ChemSpider	23277909 Y
UNII	HYS2YS4WNM
CompTox Dashboard (EPA)	DTXSID60658824
Chemical and physical data
Formula	C26H24FNO
Molar mass	385.482 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCCCCN1C=C(C=C1C2=CC(=CC=C2)F)C(=O)C3=CC=CC4=CC=CC=C43
InChI InChI=1S/C26H24FNO/c1-2-3-6-15-28-18-21(17-25(28)20-11-7-12-22(27)16-20)26(29)24-14-8-10-19-9-4-5-13-23(19)24/h4-5,7-14,16-18H,2-3,6,15H2,1H3 Y Key:OCOICOMCAJNSCA-UHFFFAOYSA-N Y

JWH-368 ([5-(3-Fluorophenyl)-1-pentylpyrrol-3-yl]-naphthalen-1-ylmethanone) is a synthetic cannabinoid from the naphthoylpyrrole family which acts as an agonist of the CB₁ (K_i = 16 ± 1nM) and CB₂ (K_i = 9.1 ± 0.7nM) receptors, binding ~1.76 times stronger to the CB₂ receptor than to the CB₁ receptor. JWH-368 was first synthesized in 2006 by John W. Huffman and colleagues to examine the nature of ligand binding to the CB₁ receptor.

Legality

In the United States JWH-368 is not federally scheduled, although some states have passed legislation banning the sale, possession, and manufacture of JWH-368.

In Canada, JWH-368 and other naphthoylpyrrole-based cannabinoids are Schedule II controlled substances under the Controlled Drugs and Substances Act.

In the United Kingdom, JWH-368 and other naphthoylpyrrole-based cannabinoids are considered Class B drugs under the Misuse of Drugs Act 1971.

See also

• List of JWH cannabinoids
• Synthetic cannabinoid