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CB1 receptor agonists
JWH-373
Другие языки:

    JWH-373

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    JWH-373
    JWH-373.svg
    Legal status
    Legal status
    Identifiers
    • [5-(2-butylphenyl)-1-pentylpyrrol-3-yl]-naphthalen-1-ylmethanone
    CAS Number
    PubChem CID
    ChemSpider
    Chemical and physical data
    Formula C30H33NO
    Molar mass 423.600 g·mol−1
    3D model (JSmol)
    • O=C(C=1C=C(C=2C=CC(=CC2)CCCC)N(C1)CCCCC)C3=CC=CC=4C=CC=CC43
    • InChI=1S/C30H33NO/c1-3-5-11-20-31-22-25(21-29(31)27-18-10-8-15-24(27)13-6-4-2)30(32)28-19-12-16-23-14-7-9-17-26(23)28/h7-10,12,14-19,21-22H,3-6,11,13,20H2,1-2H3 checkY
    • Key:LDGBUSJKRUNXPK-UHFFFAOYSA-N checkY

    JWH-373 ([5-(2-butylphenyl)-1-pentylpyrrol-3-yl]-naphthalen-1-ylmethanone) is a synthetic cannabinoid from the naphthoylpyrrole family which acts as an agonist of the CB1 (Ki = 60 ± 3nM) and CB2 (Ki = 69 ± 2nM) receptors, with a slight selectivity for the former. JWH-373 was first synthesized in 2006 by John W. Huffman and colleagues to examine the nature of ligand binding to the CB1 receptor.

    Legality

    In the United States JWH-373 is not federally scheduled, although some states have passed legislation banning the sale, possession, and manufacture of JWH-373.

    In Canada, JWH-373 and other naphthoylpyrrole-based cannabinoids are Schedule II controlled substances under the Controlled Drugs and Substances Act.

    In the United Kingdom, JWH-373 and other naphthoylpyrrole-based cannabinoids are considered Class B drugs under the Misuse of Drugs Act 1971.

    See also



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