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Eli Lilly and Company
LY-2183240
Другие языки:

LY-2183240

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LY-2183240
LY-2183240 Structure.svg
Names
IUPAC name
N,N-dimethyl-5-[(4-biphenyl)methyl]tetrazole-1-carboxamide
Identifiers
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.189.657
PubChem CID
UNII
  • InChI=1S/C17H17N5O/c1-21(2)17(23)22-16(18-19-20-22)12-13-8-10-15(11-9-13)14-6-4-3-5-7-14/h3-11H,12H2,1-2H3
    Key: GZNIYOXWFCDBBJ-UHFFFAOYSA-N
  • InChI=1/C17H17N5O/c1-21(2)17(23)22-16(18-19-20-22)12-13-8-10-15(11-9-13)14-6-4-3-5-7-14/h3-11H,12H2,1-2H3
    Key: GZNIYOXWFCDBBJ-UHFFFAOYAF
  • CN(C)C(=O)n1nnnc1Cc2ccc(cc2)-c3ccccc3
Properties
C17H17N5O
Molar mass 307.349
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

LY-2183240 is a drug which acts both as a potent inhibitor of the reuptake of the endocannabinoid anandamide and as an inhibitor of fatty acid amide hydrolase (FAAH), the primary enzyme responsible for degrading anandamide. This leads to markedly elevated anandamide levels in the brain, and LY-2183240 has been shown to produce both analgesic and anxiolytic effects in animal models. While LY-2183240 is a potent inhibitor of FAAH, it has relatively poor selectivity and also inhibits several other enzyme side targets. Consequently, it was never developed for clinical use, though it remains widely used in research, and has also been sold as a designer drug.

See also

Further reading

Moore, S. A.; Nomikos, G. G.; Dickason-Chesterfield, A. K.; Schober, D. A.; Schaus, J. M.; Ying, B. P.; Xu, Y. C.; Phebus, L; Simmons, R. M.; Li, D; Iyengar, S; Felder, C. C. (2005). "Identification of a high-affinity binding site involved in the transport of endocannabinoids". Proceedings of the National Academy of Sciences. 102 (49): 17852–7. doi:10.1073/pnas.0507470102. PMC 1295594. PMID 16314570.


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