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Liranaftate

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Liranaftate

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Liranaftate
Clinical data

Trade names	Zefnart
Other names	M-732; piritetrate
Routes of administration	Topical
ATC code	D01AE25 (WHO)
Legal status
Legal status	JP: Rx-only
Identifiers
IUPAC name O-(5,6,7,8-Tetrahydronaphthalen-2-yl) N-(6-methoxypyridin-2-yl)-N-methylcarbamothioate
CAS Number	88678-31-3
PubChem CID	3936
ChemSpider	3799
UNII	5253IGO5X3
KEGG	D01550
CompTox Dashboard (EPA)	DTXSID6046470
Chemical and physical data
Formula	C₁₈H₂₀N₂O₂S
Molar mass	328.43 g·mol⁻¹

Liranaftate (trade name Zefnart) is a topical antifungal drug. It is used as a 2% cream used to treat tinea pedis (athlete's foot), tinea corporis (ringworm), and tinea cruris (jock itch). It was approved for use in Japan in August 2000.

Liranaftate works by inhibiting the fungal enzyme squalene epoxidase that is necessary for the fungus to synthesize sterols which are essential for cell membrane integrity.