List of Ebola outbreaks

Ebola virus (SEM)

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Western African Ebola virus epidemic
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Nations with widespread cases
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Mali Nigeria Senegal Spain United States United Kingdom Italy
Other outbreaks
List of Ebola outbreaks 1976 Zaire Ebola virus outbreak 2014 DR Congo outbreak Kivu Ebola epidemic List of epidemics and pandemics
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This list of Ebola outbreaks records the known occurrences of Ebola virus disease, a highly infectious and acutely lethal viral disease that has afflicted humans and animals primarily in equatorial Africa. The pathogens responsible for the disease are the five ebolaviruses recognized by the International Committee on Taxonomy of Viruses: Ebola virus (EBOV), Sudan virus (SUDV), Reston virus (RESTV), Taï Forest virus (TAFV), and Bundibugyo virus (BDBV). Four of the five variants have caused the disease in humans as well as other animals; RESTV has caused clinical symptoms only in non-human primates. RESTV has caused subclinical infections in humans, producing an antibody response but no visual symptoms or disease state manifestations.

Transmission of the ebolaviruses between natural reservoirs and humans is rare, and outbreaks of Ebola virus disease are often traceable to a single case where an individual has handled the carcass of a gorilla, chimpanzee, bats, or duiker. The virus then spreads person-to-person, especially within families, in hospitals, and during some mortuary rituals where contact among individuals becomes more likely.

Learning from failed responses, such as during the 2000 outbreak in Uganda, the World Health Organization (WHO) established its Global Outbreak Alert and Response Network, and other public health measures were instituted in areas at high risk. Field laboratories were established to confirm cases, instead of shipping samples to South Africa. Outbreaks are also closely monitored by the United States Centers for Disease Control and Prevention (CDC) Special Pathogens Branch.

Nigeria was the first country in western Africa to successfully curtail the virus, and its procedures have served as a model for other countries to follow.

Events

The information in the following tables comes from the World Health Organization (WHO). This data excludes all laboratory personnel cases, Reston virus cases (since they are all asymptomatic), and suspected cases. For a complete overview, those cases are included below with footnotes and supporting sources.

Major or massive cases

Date	Country	Virus	Human cases	Human deaths	Case fatality rate	Description
Jun–Nov 1976	Sudan	SUDV	284	151	53%	Occurred in Nzara (the source town), Maridi, Tumbura, and Juba (cities in present-day South Sudan). The index cases were workers in a cotton factory. The disease was spread by close contact with an acute case, usually from patients to their nurses. Many medical care personnel were infected.
Aug 1976	Zaire	EBOV	318	280	88%	Main article: 1976 Zaire Ebola virus outbreak Occurred in Yambuku and surrounding areas in what was then Zaire (present-day Democratic Republic of the Congo DRC). It spread through personal contact and by use of contaminated needles and syringes in hospitals and clinics.
Aug–Sep 1979	Sudan	SUDV	34	22	65%	Occurred in Nzara and Maridi. This was a recurrent outbreak at the same site as the 1976 Sudan epidemic.
Dec 1994–Feb 1995	Gabon	EBOV	52	31	60%	Occurred in Makokou and gold-mining camps deep in the rainforest along the Ivindo River. Until 1995, the outbreak was incorrectly classified as yellow fever.
May–Jul 1995	Zaire	EBOV	315	254	81%	Occurred in Kikwit and surrounding areas. The outbreak was traced to a patient who worked in a forest adjoining the city. The epidemic spread through families and hospital admissions.
Jan–Apr 1996	Gabon	EBOV	31	21	68%	Occurred in the village of Mayibout 2 and neighboring areas. A chimpanzee found dead in the forest was eaten by villagers hunting for food. Nineteen people involved in the butchery of the animal became ill, and other cases occurred in their family members.
Jul 1996–Mar 1997	Gabon	EBOV	60	45	75%	Occurred in the Booué area with transport of patients to Libreville. The index case-patient was a hunter who lived in a forest timber camp. The disease was spread by close contact with infected persons. A dead chimpanzee found in the forest at the time was determined to be infected.
Oct 2000–Jan 2001	Uganda	SUDV	425	224	53%	Occurred in the Gulu, Masindi, and Mbarara districts of Uganda. The three greatest risks associated with Sudan virus infection were attending funerals of case-patients, having contact with case-patients in one's family, and providing medical care to case-patients without using adequate personal protective measures. Victims included Matthew Lukwiya.
Oct 2001–Jul 2002	Gabon	EBOV	65	53	82%	Occurred on both sides of the border between Gabon and the Republic of the Congo.
Oct 2001–Jul 2002	ROC	EBOV	59	44	75%	Occurred on both sides of the border between Gabon and the Republic of the Congo (RC). This outbreak included the first reported occurrence of Ebola virus disease in the RC.
Dec 2002–Apr 2003	ROC	EBOV	143	128	90%	Occurred in the districts of Mbomo and Kelle in the Cuvette-Ouest Department.
Nov–Dec 2003	ROC	EBOV	35	29	83%	Occurred in Mbomo and Mbandza villages, located in Mbomo District in the Cuvette-Ouest Department.
Apr–Jun 2004	Sudan	SUDV	17	7	41%	Occurred in Yambio county in Western Equatoria of southern Sudan (present-day South Sudan). This outbreak was concurrent with an outbreak of measles in the same area, and several suspected EVD cases were reclassified later as measles cases.
Apr-May 2005	ROC	EBOV	12	10	83%	Occurred in the Etoumbi district of Cuvette Ouest Department of the Republic of the Congo
Aug–Nov 2007	DRC	EBOV	264	187	71%
Dec 2007–Jan 2008	Uganda	BDBV	149	37	25%	Occurred in the Bundibugyo District in western Uganda. This was the first identification of the Bundibugyo virus (BDBV).
Dec 2008–Feb 2009	DRC	EBOV	32	14	45%	Occurred in the Mweka and Luebo health zones of the Kasaï-Occidental province.
Jun–Aug 2012	Uganda	SUDV	24	17	71%	Occurred in the Kibaale District.
Jun–Nov 2012	DRC	BDBV	57	29	51%	Occurred in the Orientale Province.
Dec 2013–Jun 2016	Widespread:  Liberia  Sierra Leone  Guinea Limited and local:  Nigeria  Mali  United States  Senegal  Spain  United Kingdom  Italy	EBOV	28,616	11,310	70–71% (general) 57–59% (among hospitalized patients)	Main article: West African Ebola virus epidemic This was the most severe Ebola outbreak in recorded history in regards to both the number of human cases and fatalities. It began in Guéckédou, Guinea, in December 2013 and spread abroad. Flare-ups of the disease continued into 2016, and the outbreak was declared over on 9 June 2016.
Aug–Nov 2014	DRC	EBOV	66	49	74%	Main article: 2014 Democratic Republic of the Congo Ebola virus outbreak Occurred in Équateur province. Outbreak detected 24 August and, as of 28 October 2014, the WHO said that twenty days had passed since the last reported case was discharged and no new contacts were being followed. Declared over on 15 November 2014.
May–Jul 2018	DRC	EBOV	54	33	61%	Main article: 2018 Équateur province Ebola outbreak On 8 May 2018, the government of the Democratic Republic of the Congo reported two confirmed cases of Ebola infection in the northwestern town of Bikoro. On 17 May, a case was confirmed in the city of Mbandaka. Health authorities were planning to ring vaccinate with rVSV-ZEBOV, a recently developed experimental Ebola vaccine, to contain the outbreak. The outbreak was ongoing as of 24 June 2018, in 2014 a different area of Equateur province was affected On 24 July 2018 the outbreak was declared over.
Aug 2018–Jun 2020	Widespread: DRC Limited and local:  Uganda	EBOV	3,470	2,280	66%	Main article: Kivu Ebola epidemic On 1 August 2018, the Democratic Republic of the Congo Ministry of Health declared an outbreak when 4 individuals tested positive for the Ebola virus. On 11 June 2019, the WHO confirmed that a five-year-old boy in Uganda died after being diagnosed with Ebola. On 25 June 2020, the second biggest EVD outbreak ever was declared over.
May 2020–Nov 2020	DRC	EBOV	130	55	42%	Main article: 2020 Équateur province Ebola outbreak On 31 May 2020, the DRC Health Minister Eteni Longondo announced an additional Ebola outbreak, separate to the ongoing Kivu Ebola epidemic. The outbreak originated in Équateur province (which was also the location of the 2018 Équateur province Ebola outbreak). By 17 October 2020, the case count was 128 with 53 fatalities. By 18 November 2020, the World Health Organization and the Congolese government had not received reports of any cases of Ebola in Équateur province or all of the DRC for 42 days. When the outbreak was declared over, there were 130 reported cases and 55 reported fatalities due to the virus.
Feb–May 2021	DRC	EBOV	12	6	50%	On 6 February 2021, an outbreak was declared in Butembo in the North Kivu province by the Ministry of Public Health of the Democratic Republic of the Congo. By 3 May 2021, the outbreak was declared over.
Feb–Jun 2021	Guinea	EBOV	23	12	52%	First Ebola cases and deaths in the country since 2016. The first cases were confirmed on 14 February 2021, and by 9 April 2021, there were 23 reported cases of the virus, with 12 fatalities and 9 recoveries. Scientists concluded that the likely source of the outbreak was a man who had survived the 2013-2016 West African epidemic but had unknowingly harbored the Ebola virus in his body, eventually transmitting it to somebody in his community, although the first known case of this current outbreak was a female nurse who had died on 28 January 2021. The outbreak was declared over on 19 June 2021.
Oct–Dec 2021	DRC	EBOV	11	9	82%	On 8 October 2021, the Ministry of Public Health for the Democratic Republic of the Congo reported a new laboratory confirmed case of Ebola virus disease, ten more related cases were later confirmed. On 16 December the outbreak was declared over.
Sept 2022–Jan 2023	UGA	SUDV	164	77		Main article: 2022 Uganda Ebola outbreak On 20 September 2022 an outbreak was declared in Mubende District, Uganda. Seventy-seven people died, with a total of 164 cases detected. The outbreak was declared over in January 2023.

Minor or single cases

Date	Country	Virus	Human cases	Human deaths	Description
1976	United Kingdom	SUDV or EBOV	1	0	Laboratory infection by accidental stick of contaminated needle.
1977	Zaire	EBOV	1	1	Noted retroactively in the village of Tandala.
1989–1990	Philippines	RESTV	3	0	The Reston virus (RESTV) was first identified when it caused high mortality in crab-eating macaques in a primate research facility responsible for exporting animals to the United States. Three workers in the facility developed antibodies to the virus but did not get sick.
1989	United States	RESTV	0	0	RESTV was introduced into quarantine facilities in Virginia and Pennsylvania by monkeys imported from the Philippines. No human cases were reported.
1990	United States	RESTV	4	0	Monkeys imported from the Philippines introduced RESTV into quarantine facilities in Virginia and Texas. Four humans developed antibodies but did not get sick.
1992	Italy	RESTV	0	0	RESTV was introduced into quarantine facilities in Siena by monkeys imported from the same facility in the Philippines that was the source of the 1989 and 1990 U.S. outbreaks. No human cases resulted.
1994	Côte d'Ivoire	TAFV	1	0	This case was the first and thus far only recognition of Taï Forest virus (TAFV). Approximately one week after conducting necropsies on infected western chimpanzees in Taï National Park, a scientist contracted the virus and developed symptoms similar to those of dengue fever. She was discharged from a Swiss hospital two weeks later and fully recovered after six weeks.
1995	Côte d'Ivoire	Unknown	1	0	One person, fleeing the civil war in neighboring Liberia, was identified as an Ebola case in Gozon. This is considered as a suspected case, excluding from the WHO outbreak counts.
1996	South Africa	EBOV	1	1	n/a
1996	United States	RESTV	0	0	RESTV was again introduced into a quarantine facility in Texas by monkeys imported from the same facility in the Philippines that was the source of the 1989 and 1990 U.S. outbreaks. No human cases resulted.
1996	Philippines	RESTV	0	0	RESTV was identified at a monkey export facility in the Philippines. No human cases resulted.
1996	Russia	EBOV	1	1	Laboratory contamination.
2004	Russia	EBOV	1	1	Laboratory contamination.
2008	Philippines	RESTV	6	0	First recognition of RESTV in pigs. Strain very similar to earlier strains. Occurred in November. Six workers from the pig farm and slaughterhouse developed antibodies but did not become sick.
2011	Uganda	SUDV	1	1	n/a
2012	Uganda	SUDV	7	4	n/a
2015	Philippines	RESTV	0	0	On 6 September 2015, the Philippine health secretary reported an outbreak of RESTV in a primate research and breeding facility. Twenty-five workers subsequently tested negative for the virus.
2017	DRC	EBOV	8	4	Main article: 2017 Democratic Republic of the Congo Ebola virus outbreak On 11 May 2017, the Ministry of Public Health for the Democratic Republic of the Congo notified the WHO of an Ebola outbreak in the Likati health zone (LHZ) in Bas-Uele province, in the northern part of the country. Suspected infections were reported from Nambwa, Mouma, and Ngay. The LHZ borders the Central African Republic, which made this outbreak a moderate risk to the region.
2018	Hungary	N/A	0	0	On 20 April 2018, a laboratory accident led to a single worker being exposed to the Ebola virus, though he did not develop symptoms.
2022	DRC	EBOV	5	5	An outbreak in DRC began on April 23, and has killed 100% of those infected.
2022	DRC	EBOV	1	1	A single case was confirmed in North Kivu.

List of other Filoviridae outbreaks

Marburg virus disease outbreaks

Year	Country	Virus	Human cases	Human deaths	Case fatality rate	Comments
1967	West Germany  Yugoslavia	MARV	31	7	23%	Main article: 1967 Marburg virus outbreak in West Germany In 1967 outbreaks in Marburg, Germany where the virus was first identified (historically) and the subsequent naming of the virus per the location
1975	Rhodesia  South Africa	MARV	3	1	33%	Individual had traveled to Zimbabwe
1980	Kenya	MARV	2	1	50%	Individual(s) traveled to Kitum Cave
1987	Kenya	RAVV	1	1	100%	Ravn virus (RAVV) one of two members of the species Marburg marburgvirus
1990	Soviet Union	MARV	1	1	100%	Laboratory incident
1998–2000	DRC	MARV & RAVV	154	128	83%	Occurred in Durba
2004–2005	Angola	MARV	252	227	90%	Largest Marburg virus outbreak ever occurred in Angola
2007	Uganda	MARV & RAVV	4	1	25%	Occurred in Kamwenge
2008	Uganda  Netherlands  United States	MARV	2	1	50%	-
2012	Uganda	MARV	15	4	27%	Occurred in Kabale
2014	Uganda	MARV	1	1	100%	-
2017	Uganda	MARV	3	3	100%	Main article: 2017 Uganda Marburg virus outbreak Uganda has had five outbreaks of the virus
2021	Guinea	MARV	1	1	100%	Main article: 2021 Marburg virus disease outbreak in Guinea In August 2021, two months after the re-emergent Ebola epidemic in the Guéckédou prefecture was declared over, a case of the Marburg virus disease was confirmed by health authorities through laboratory analysis. This is the first-ever case of the Marburg virus disease in West Africa. On August 2, the patient succumbed to the illness.
2022	Ghana	MARV	3	3	100%	First time Ghana has had cases of Marburg virus disease
2023	Equatorial Guinea	MARV	25	11	44%	Main article: 2023 Marburg virus disease outbreak in Equatorial Guinea First time Marburg virus disease was detected in the country.
2023	Tanzania	MARV	8	5	62%	First time Marburg virus disease was detected in the country.

See also

• Ebola
• Ebola River
• Globalization and disease
• List of epidemics

Further reading

• de Meneses Rocha Pacheco, Daniela Alexandra; Rodrigues, Acácio Agostinho Gonçalves; da Silva, Carmen Maria Lisboa (August 2016). "Ebola virus – from neglected threat to global emergency state" (PDF). Revista da Associação Médica Brasileira. Associação Médica Brasileira. 62 (5): 458–467. doi:10.1590/1806-9282.62.05.458. ISSN 1806-9282. PMID 27656857. S2CID 9073931 – via SciELO.
• Park, Sung-Joon (March 2021). "Deadly secret: situating the unknowing and knowing of the source of the Ebola epidemic in Northern Uganda". Journal of the Royal Anthropological Institute. Wiley-Blackwell on behalf of the Royal Anthropological Institute. 27 (2): 227–244. doi:10.1111/1467-9655.13488. ISSN 1467-9655. S2CID 233606310.