List of adverse effects of paroxetine

This is a list of adverse effects of the antidepressant paroxetine, sorted by frequency of occurrence.

Very common

Very common (10-100% incidence) adverse effects include:

• Nausea
• Sexual dysfunction (including anorgasmia (difficulty achieving an orgasm), erectile dysfunction, genital anaesthesia, ejaculation disorder, loss of libido etc.). Paroxetine is associated with a higher rate of sexual dysfunction than other SSRIs.
• Impaired concentration
• Somnolence is more common with paroxetine than with other SSRIs.
• Insomnia
• Headache
• Dry mouth

Common

Common (1-10% incidence) adverse effects include:

Uncommon

Uncommon (0.1-1% incidence) adverse effects include:

Rare

Rare (0.01-0.1% incidence) adverse effects include:

Very rare

Rare (<0.01% incidence) adverse effects include:

• Thrombocytopenia
• Syndrome of inappropriate secretion of antidiuretic hormone (SIADH)
• Serotonin syndrome (symptoms may include agitation, confusion, diaphoresis, hallucinations, hyperreflexia, myoclonus, shivering, tachycardia and tremor)
• Gastrointestinal bleeding
• Hepatic events (such as hepatitis, sometimes associated with jaundice and/or liver failure)
• Priapism
• Severe cutaneous adverse reactions (including erythema multiforme, Stevens–Johnson syndrome and toxic epidermal necrolysis)
• Photosensitivity reactions