List of side effects of trimethoprim/sulfamethoxazole
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Adverse effects by incidence of trimethoprim/sulfamethoxazole
Common (>1% frequency)
- Fever
- Nausea
- Vomiting
- Diarrhea
- Weight loss
- Rash
- Muscle aches
- Joint pain
- Itch
- Sore mouth
- Hyperkalaemia (high blood potassium)
- Thrombocytopenia (low number of platelets in the blood)
Infrequently (0.1–1.0% frequency)
- Headache
- Jaundice
- Elevated liver transaminases
- Peripheral neuritis
- Drowsiness
- Constipation
- Photosensitivity (light sensitivity)
- Blood dyscrasias (e.g. neutropaenia)
Rare (<0.1% frequency)
- Megaloblastic anaemia
- Methaemoglobinaemia
- Erythema multiforme
- Low blood sugar
- Hepatitis (liver swelling)
- Crystalluria (crystals in the urine)
- Urinary obstruction causing difficulty passing urine
- Lowered mental acuity
- Depression
- Tremor
- Aplastic anaemia
- Haemolytic anaemia
- Hyponatraemia
- Purpura
- Eosinophilia
- Agranulocytosis
- Serum sickness
- Anaphylaxis
- Allergic myocarditis
- Angioedema
- Drug fever
- Periarteritis nodosa
- Hepatic necrosis
- Pancreatitis
- Myelosuppression
- Haemolysis
- Stevens–Johnson syndrome
- Drug reaction with eosinophilia and systemic symptoms
- Toxic epidermal necrolysis
- Ataxia
- Clostridium difficile colitis
- Aseptic meningitis
- Pseudomembranous colitis
- Interstitial nephritis
- Fulminant hepatic necrosis
- Hypersensitivity of the respiratory tract
- Sore throat
- Pallor
- Arthralgia
Unknown frequency
- Hallucinations
- Cough
- Glossitis
- Stomatitis
- Fatigue
- Insomnia
- Impaired kidney function
- Pulmonary infiltration
- Shortness of breath