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Abandoned drugs
Locicortolone
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    Locicortolone

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    Locicortolone
    Locicortolone.svg
    Clinical data
    Other names Locicortone; RU-24476; 9α,11β-Dichloro-21-hydroxy-16α-methylpregna-1,4-diene-3,20-dione
    Drug class Corticosteroid; Glucocorticoid
    Identifiers
    • (8S,9R,10S,11S,13S,14S,16R,17S)-9,11-Dichloro-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,11,12,14,15,16,17-octahydro-6H-cyclopenta[a]phenanthren-3-one
    CAS Number
    PubChem CID
    ChemSpider
    UNII
    CompTox Dashboard (EPA)
    Chemical and physical data
    Formula C22H28Cl2O3
    Molar mass 411.36 g·mol−1
    3D model (JSmol)
    • C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@H]1C(=O)CO)C)Cl)Cl)C
    • InChI=1S/C22H28Cl2O3/c1-12-8-16-15-5-4-13-9-14(26)6-7-21(13,3)22(15,24)18(23)10-20(16,2)19(12)17(27)11-25/h6-7,9,12,15-16,18-19,25H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,18+,19-,20+,21+,22+/m1/s1
    • Key:FKRMBGXNTOTQDI-IIEHVVJPSA-N

    Locicortolone (developmental code name RU-24476), or locicortone, is a synthetic glucocorticoid corticosteroid which was never marketed.




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