Мы используем файлы cookie.
Продолжая использовать сайт, вы даете свое согласие на работу с этими файлами.
Продолжая использовать сайт, вы даете свое согласие на работу с этими файлами.
Nepinalone
Подписчиков: 0, рейтинг: 0
Clinical data | |
---|---|
ATC code | |
Identifiers | |
| |
CAS Number | |
PubChem CID | |
ChemSpider |
|
UNII | |
KEGG |
|
Chemical and physical data | |
Formula | C18H25NO |
Molar mass | 271.404 g·mol−1 |
3D model (JSmol) | |
| |
| |
(verify) |
Nepinalone is a cough suppressant. Its brand names include Placatus, Tussolvina, and Nepitus.
The effect is evident after 20–30 minutes after administration and persists for at least 4 hours. It acts primarily at the level of the CNS, but also shows a slight activity in inhibiting the bronchospasm. In such use, it is less effective than codeine and more effective than dextromethorphan in inhibiting the tussive stimulus. [1]
Synthesis
The starting material is called 2-Phenylpropanoyl Chloride [22414-26-2]. This is reacted with ethylene in the presence of aluminum trichloride catalyst to give 1-methyl-2-tetralone [66405-14-9] (1). Base catalyzed alkylation of this with 1-(2-chloroethyl)piperidine [1932-03-2] (2) gives Nepinalone (3).
σ1 |
|
---|---|
σ2 | |
Unsorted |
|
See also: Receptor/signaling modulators |