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Experimental drugs
ORG-26576
Другие языки:

ORG-26576

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ORG-26576
Org 26576.svg
Identifiers
  • (7S)-9-oxa-3,11-diazatricyclo[8.4.0.03,7]tetradeca-1(10),11,13-trien-2-one
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
Formula C11H12N2O2
Molar mass 204.229 g·mol−1
3D model (JSmol)
  • C1C[C@H]2COC3=C(C=CC=N3)C(=O)N2C1
  • InChI=1S/C11H12N2O2/c14-11-9-4-1-5-12-10(9)15-7-8-3-2-6-13(8)11/h1,4-5,8H,2-3,6-7H2/t8-/m0/s1
  • Key:FIKUEZUFASUKAH-QMMMGPOBSA-N

ORG-26576 is an ampakine originally developed by Cortex Pharmaceuticals and then licensed to Organon International for development. In animal studies it has been shown to effectively potentiate AMPA receptor function, leading to increased BDNF release and enhanced neuronal differentiation and survival, as well as producing nootropic effects in standardised assays. Development as an antidepressant has been halted due to a failed Phase II trial for major depressive disorder.

See also



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