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Obafluorin
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IUPAC name
2,3-dihydroxy-N-[(2R,3S)-2-[(4-nitrophenyl)methyl]-4-oxooxetan-3-yl]benzamide
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Identifiers | |
3D model (JSmol)
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PubChem CID
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CompTox Dashboard (EPA)
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Properties | |
C17H14N2O7 | |
Molar mass | 358.306 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Obafluorin is a β-lactone antibiotic with the molecular formula C17H14N2O7. Obafluorin is produced by the bacterium Pseudomonas fluorescens. Obafluorin is a inhibitor of serine hydroxymethyltransferase.
Further reading
- "Next antibiotic may come from dirt bacteria". Futurity. 2 August 2019.
- Scott, Thomas A.; Heine, Daniel; Qin, Zhiwei; Wilkinson, Barrie (26 June 2017). "An L-threonine transaldolase is required for L-threo-β-hydroxy-α-amino acid assembly during obafluorin biosynthesis". Nature Communications. 8 (1): 15935. doi:10.1038/ncomms15935. ISSN 2041-1723. PMC 5490192. PMID 28649989.
- Herbert, Richard B.; Knaggs, Andrew R. (1992). "Biosynthesis of the antibiotic obafluorin from D-[U-13C]glucose and p-aminophenylalanine in Pseudomonas fluorescens". Journal of the Chemical Society, Perkin Transactions 1 (1): 103–107. doi:10.1039/P19920000103. ISSN 1364-5463.