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Oportuzumab monatox
Monoclonal antibody | |
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Type | Single-chain variable fragment |
Source | Humanized |
Target | EpCAM |
Clinical data | |
Other names | oportuzumab monatox-qqrs |
ATC code | |
Identifiers | |
CAS Number | |
DrugBank |
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ChemSpider |
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Chemical and physical data | |
Formula | C3072H4723N877O952S12 |
Molar mass | 69558.48 g·mol−1 |
NY (what is this?) (verify) |
Oportuzumab monatox is an experimental anti-cancer medication. Chemically, oportuzumab is a single chain variable fragment of a monoclonal antibody which binds to epithelial cell adhesion molecule (EpCAM, the tumor-associated calcium signal transducer 1). Oportuzumab is fused with Pseudomonas aeruginosa exotoxin A (which is reflected by the monatox in the medication's name).
The drug was developed by Canadian-based Viventia Bio Inc. The company was acquired by Cambridge(MA)-based Eleven Biotherapeutics in 2016, which then changed its name to Sesen Bio. In 2019 Sesen Bio reported updated, preliminary primary and secondary endpoint data from the company's Phase 3 VISTA trial further supporting the strong benefit-risk profile of Vicineum for the potential treatment of patients with high-risk, bacillus Calmette-Guérin(BCG) unresponsive, non-muscle invasive bladder cancer (NMIBC). The Company applied for approval of Vicineum by the United States Food and Drug Administration and the European Medicines Agency.
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