PABPC5

PABPC5
Identifiers
Aliases	PABPC5, PABP5, poly(A) binding protein cytoplasmic 5
External IDs	OMIM: 300407 MGI: 2136401 HomoloGene: 5857 GeneCards: PABPC5
Gene location (Human) Chr. X chromosome (human) Band Xq21.31 Start 91,434,595 bp End 91,438,584 bp
Gene location (Mouse) Chr. X chromosome (mouse) Band X|X E1 Start 118,836,893 bp End 118,839,862 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon Left adrenal gland smooth muscle tissue islet of Langerhans popliteal artery ganglionic eminence left coronary artery ascending aorta right coronary artery gastric mucosa Top expressed in superior frontal gyrus cerebellar cortex neural tube mirror mesencephalon hippocampus proper olfactory bulb uterus supraoptic nucleus retina More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 140886 93728 Ensembl ENSG00000174740 ENSMUSG00000034732 UniProt Q96DU9 Q8C7D3 RefSeq (mRNA) NM_080832 NM_053114 RefSeq (protein) NP_543022 NP_444344 Location (UCSC) Chr X: 91.43 – 91.44 Mb Chr X: 118.84 – 118.84 Mb PubMed search
Wikidata
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Poly(A) binding protein cytoplasmic 5 is a protein that in humans is encoded by the PABPC5 gene.

Function

This gene encodes a poly(A)-binding protein that binds to the polyA tail found at the 3' end of most eukaryotic mRNAs. It is thought to play a role in the regulation of mRNA metabolic processes in the cytoplasm. This gene is located in a gene-poor region within the X-specific 13d-sY43 subinterval of the chromosome Xq21.3/Yp11.2 homology block. It is located close to translocation breakpoints associated with premature ovarian failure, and is therefore a potential candidate gene for this disorder. [provided by RefSeq, May 2010].

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.