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PD-0298029
Другие языки:

    PD-0298029

    Подписчиков: 0, рейтинг: 0
    PD-0298029
    PD0298029 structure.png
    Identifiers
    • ethyl 3,6a,11,14-tetrahydro-9-methoxy-2-propyl-3,5-dimethyl-(12H)-isoquino[1,2-b]pyrrolo[3,2-f][1,3]benzoxazine-1-carboxylate
    ChemSpider
    Chemical and physical data
    Formula C27H32N2O4
    Molar mass 448.563 g·mol−1
    3D model (JSmol)
    • CCCc1c(c2c(n1C)cc(c3c2CN4CCc5cc(ccc5C4O3)OC)C)C(=O)OCC

    • CCCc1n(C)c5cc(C)c3OC4c2ccc(OC)cc2CCN4Cc3c5c1C(=O)OCC
    • InChI=1S/C27H32N2O4/c1-6-8-21-24(27(30)32-7-2)23-20-15-29-12-11-17-14-18(31-5)9-10-19(17)26(29)33-25(20)16(3)13-22(23)28(21)4/h9-10,13-14,26H,6-8,11-12,15H2,1-5H3 checkY
    • Key:MTMZSGQXRVRKSY-UHFFFAOYSA-N checkY
      (verify)

    PD-0298029 is a drug which acts as a selective antagonist for the muscarinic acetylcholine receptor M4. It was developed for the treatment of Parkinson's disease, but poor bioavailability and rapid metabolism in animal studies have meant its use is largely limited to in vitro research into the M4 and other muscarinic receptors.

    See also



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