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Microbicides
PRO 2000
Другие языки:

    PRO 2000

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    PRO 2000
    Clinical data
    Other names 2-Naphthalenesulfonic acid, sodium salt, polymer with formaldehyde
    Identifiers
    • Sodium 2-naphthalenesulfonate, polymer with formaldehyde
    CAS Number
    ChemSpider
    • none
    NIAID ChemDB
    CompTox Dashboard (EPA)
    ECHA InfoCard 100.111.201
    Chemical and physical data
    Formula (C10H8O3S.CH2O.Na)x
    Molar mass Approximately 5 kg/mol

    PRO 2000 is an experimental vaginal microbicide which has been proposed as a preventive medicine for reducing the risk of contracting HIV. It has never been recommended as an effective medicine to be used for any purpose. Some clinical trials have shown that under some conditions it may provide some protection against HIV.

    History

    Endo Pharmaceuticals manufactures the drug.

    Efficacy

    Animal testing studies done on macaques have shown that PRO 2000 is effective in preventing the transmission of HIV. Other studies have given supportive evidence that the product is safe in humans and would be an appropriate candidate for testing.

    A phase III clinical trial of 9385 women in sub-Saharan Africa showed that PRO 2000 was not effective in preventing transmission of HIV.


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