Phyloscan
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| Developer(s) | Wadsworth Center, New York State Department of Health |
|---|---|
| Initial release | March 14, 2005 (2005-03-14) |
| Stable release | 2.2
/ January 28, 2010 (2010-01-28)
|
| Platform | web service |
| Available in | English |
| Type | Bioinformatics tool |
| Website | http://ccmbweb.ccv.brown.edu/cgi-bin/phyloscanV2.pl |
Phyloscan is a web service for DNA sequence analysis that is free and open to all users (without login requirement). For locating matches to a user-specified sequence motif for a regulatory binding site, Phyloscan provides a statistically sensitive scan of user-supplied mixed aligned and unaligned DNA sequence data. Phyloscan's strength is that it brings together
- the Staden method for computing statistical significance,
- the "phylogenetic motif model" scanning functionality of the MONKEY software that models evolutionary relationships among aligned sequences,
- the use of the Bailey & Gribskov method for combining statistics across non-aligned sequence data, and
- the Neuwald & Green technique for combining statistics across multiple binding sites found within a single gene promoter region.