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Enzyme inhibitor
RKI-1447
Другие языки:

    RKI-1447

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    RKI-1447
    RKI-1447 structure.png
    Identifiers
    • 1-[(3-hydroxyphenyl)methyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)urea
    CAS Number
    PubChem CID
    ChemSpider
    UNII
    ChEMBL
    Chemical and physical data
    Formula C16H14N4O2S
    Molar mass 326.37 g·mol−1
    3D model (JSmol)
    • C1=CC(=CC(=C1)O)CNC(=O)NC2=NC(=CS2)C3=CC=NC=C3
    • InChI=1S/C16H14N4O2S/c21-13-3-1-2-11(8-13)9-18-15(22)20-16-19-14(10-23-16)12-4-6-17-7-5-12/h1-8,10,21H,9H2,(H2,18,19,20,22)
    • Key:GDVRVPIXWXOKQO-UHFFFAOYSA-N

    RKI-1447 is a drug which acts as a potent and selective inhibitor of the enzyme Rho kinase, with an IC50 of 14.5 nM at ROCK1 and 6.2 nM at ROCK2. It has been investigated for applications in cancer treatment, as well as glaucoma, and nonalcoholic fatty liver disease.

    See also


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