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Abandoned drugs
Regonyl
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    Regonyl

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    Regonyl
    Regonyl.svg
    Clinical data
    Other names TX-380; NSC-69588; 17α-Ethynyl-5α-androst-2-en-17β-ol 17β-acetate; 17β-Acetoxy-5α,17α-pregn-2-en-20-yne
    Identifiers
    • [(5S,8R,9S,10S,13S,14S,17R)-17-ethynyl-10,13-dimethyl-1,4,5,6,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-yl] acetate
    CAS Number
    PubChem CID
    ChemSpider
    UNII
    KEGG
    ChEBI
    CompTox Dashboard (EPA)
    Chemical and physical data
    Formula C23H32O2
    Molar mass 340.507 g·mol−1
    3D model (JSmol)
    • CC(=O)O[C@]1(CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC[C@@H]4[C@@]3(CC=CC4)C)C)C#C
    • InChI=1S/C23H32O2/c1-5-23(25-16(2)24)15-12-20-18-10-9-17-8-6-7-13-21(17,3)19(18)11-14-22(20,23)4/h1,6-7,17-20H,8-15H2,2-4H3/t17-,18-,19+,20+,21+,22+,23+/m1/s1
    • Key:SQRBBVVZRKZEPF-OWNQEUAMSA-N

    Regonyl (developmental code name TX-380), also known as 17α-ethynyl-5α-androst-2-en-17β-ol 17β-acetate, is a steroidal drug described as an antiprogestogen and "antiprolactin" (prolactin inhibitor). It was studied for lactation inhibition in bitches. It has minimal to no androgenic, estrogenic, or progestogenic activity but is said to strongly inhibit the hypothalamic–pituitary–gonadal axis at central and peripheral levels and to markedly oppose the action of progesterone. However, the antiprogestogenic effects of regonyl do not appear to be due to direct interaction with the progesterone receptor. The actions of regonyl result in estrus cycle disturbances and impaired ovulation. Regonyl was proposed for use in humans, for instance in the treatment of gynecological disorders like endometriosis and benign breast disease, and in hormonal contraception.


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