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Experimental drugs
Rovafovir etalafenamide
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    Rovafovir etalafenamide

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    Rovafovir etalafenamide
    Rovafovir etalafenamide.svg
    Legal status
    Legal status
    • Investigational
    Identifiers
    • Ethyl (2S)-2-[[[(2R,5R)-5-(6-aminopurin-9-yl)-4-fluoro-2,5-dihydrofuran-2-yl]oxymethyl-phenoxyphosphoryl]amino]propanoate
    CAS Number
    PubChem CID
    ChemSpider
    UNII
    KEGG
    ChEMBL
    Chemical and physical data
    Formula C21H24FN6O6P
    Molar mass 506.431 g·mol−1
    3D model (JSmol)
    • CCOC(=O)[C@H](C)N[P@@](=O)(CO[C@H]1O[C@@H](N2C=NC3=C2N=CN=C3N)C(F)=C1)OC4=CC=CC=C4
    • InChI=1S/C21H24FN6O6P/c1-3-31-21(29)13(2)27-35(30,34-14-7-5-4-6-8-14)12-32-16-9-15(22)20(33-16)28-11-26-17-18(23)24-10-25-19(17)28/h4-11,13,16,20H,3,12H2,1-2H3,(H,27,30)(H2,23,24,25)/t13-,16-,20+,35+/m0/s1
    • Key:OCJRRXHWPBXZSU-BJBBEUPESA-N

    Rovafovir etalafenamide (development code GS-9131) is an experimental drug for the treatment of HIV-1 infection. Rovafovir etalafenamide is a nucleotide reverse transcriptase inhibitor and prodrug of GS-9148. Rovafovir etalafenamide itself has no antiviral activity, but once consumed it is metabolized through the hydrolysis of the phosphonoamidate group to generate the antiviral compound GS-9148.

    Chemical strucuture of GS-9148, the active antiviral agent

    The drug is being developed by Gilead.

    Rovafovir etalafenamide shows antiviral activity against viruses containing major mutations associated with resistance to the nucleoside analog reverse-transcriptase inhibitors which are commonly used to treat HIV/AIDS infection.

    The methods by which the drug is synthesized by been published.


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