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Pharmacology stubs
SET2
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    SET2

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    SET2
    SET2 structure.png
    Identifiers
    • N-(furan-2-ylmethyl)-3-({4-[methyl(propyl)amino]-6-(trifluoromethyl)pyrimidin-2-yl}sulfanyl)propanamide
    ChemSpider
    Chemical and physical data
    Formula C17H21F3N4O2S
    Molar mass 402.44 g·mol−1
    3D model (JSmol)
    • O=C(CCSc1nc(cc(n1)N(C)CCC)C(F)(F)F)NCc2ccco2
    • InChI=1S/C17H21F3N4O2S/c1-3-7-24(2)14-10-13(17(18,19)20)22-16(23-14)27-9-6-15(25)21-11-12-5-4-8-26-12/h4-5,8,10H,3,6-7,9,11H2,1-2H3,(H,21,25)
    • Key:LZHSWRWIMQRTOP-UHFFFAOYSA-N

    SET2 is a drug which acts as a selective antagonist for the TRPV2 receptor. It is moderately potent with an IC50 of 460nM, but is highly selective for TRPV2 over the other subtypes of TRPV, and is the first such compound to be developed. A role has been suggested for TRPV2 in tumor metastasis, making this a target of interest in the treatment of cancer.

    See also


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