Sivelestat

Sivelestat

Clinical data
AHFS/Drugs.com	International Drug Names
Routes of administration	IV
ATC code	None
Legal status
Legal status	US: Not approved In general: ℞ (Prescription only)
Identifiers
IUPAC name N-{2-[({4-[(2,2-dimethylpropanoyl)oxy]phenyl}sulfonyl)amino]benzoyl}glycine
CAS Number	127373-66-4 N
PubChem CID	107706
IUPHAR/BPS	6441
ChemSpider	96875 Y
UNII	DWI62G0P59
KEGG	D03788 Y
ChEMBL	ChEMBL76688 Y
CompTox Dashboard (EPA)	DTXSID9048304
Chemical and physical data
Formula	C20H22N2O7S
Molar mass	434.46 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2C(=O)NCC(=O)O
InChI InChI=1S/C20H22N2O7S/c1-20(2,3)19(26)29-13-8-10-14(11-9-13)30(27,28)22-16-7-5-4-6-15(16)18(25)21-12-17(23)24/h4-11,22H,12H2,1-3H3,(H,21,25)(H,23,24) Y Key:BTGNGJJLZOIYID-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

Sivelestat (INN, research name ONO 5046, marketed as Elaspol) is an inhibitor of human neutrophil elastase.

It is used in the treatment of acute respiratory failure and preliminary studies show it may also improve neuropathic pain.

Synthesis

Sivelestat is synthesised as follows: