Sorting nexin

PX domain
Structure of the PX domain from p40(phox) bound to phosphatidylinositol 3-phosphate.
Identifiers
Symbol	PX
Pfam	PF00787
InterPro	IPR001683
SMART	PX
PROSITE	PDOC50195
SCOP2	1h6h / SCOPe / SUPFAM
OPM superfamily	57
OPM protein	4on3
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Sorting nexins are a large group of proteins that are localized in the cytoplasm and have the potential for membrane association either through their lipid-binding PX domain (a phospholipid-binding motif) or through protein–protein interactions with membrane-associated protein complexes Some members of this family have been shown to facilitate protein sorting.

Family members

In humans, sorting nexins are transcribed from the following genes:

Structure

Sorting nexins either consist solely of a PX domain (e.g. SNX3) or have a modular structure made up of the PX and additional domains.

A subgroup of sorting nexins (comprising, in humans, SNX1, SNX2, SNX4, SNX5, SNX6, SNX7, SNX8, SNX9, SNX18, SNX30, SNX32 and SNX33) possess a BAR domain at their C-terminus. (The BAR domain of SNXs 1, 2, 4, 7, 8 and 30 is classified by pfam as 'Vps5 C terminal like'.)

An example of a sorting nexin domain structure can be seen here for SNX1:

1. NTD – N-terminal domain
2. PX domain
3. CTD – C-terminal BAR domain

Schematic diagram of the 1D structures of a representative sorting nexin, the sorting nexin 1 (SNX1). NTD = N-terminal SNX domain, PX = PX domain, CTD = C-terminal BAR domain.

External links

• Sorting+Nexins at the U.S. National Library of Medicine Medical Subject Headings (MeSH)