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Sumanirole
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Sumanirole

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Sumanirole
Sumanirole.svg
Clinical data
Other names PNU-95,666
ATC code
  • none
Identifiers
  • (R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
ChEMBL
Chemical and physical data
Formula C11H13N3O
Molar mass 203.245 g·mol−1
3D model (JSmol)
  • CN[C@@H]1Cc2cccc3[nH]c(=O)n(C1)c23

Sumanirole (PNU-95,666) is a highly selective D2 receptor full agonist, the first of its kind to be discovered. It was developed for the treatment of Parkinson's disease and restless leg syndrome. While it has never been approved for medical use it is a highly valuable tool compound for basic research to identify neurobiological mechanisms that are based on a dopamine D2-linked (vs. D1-, D3-, D4-, and D5-linked) mechanism of action.

In 2004, Pfizer announced the end of their clinical development program for sumanirole, citing “recent studies that failed to sufficiently distinguish sumanirole from currently available therapies”.

See also



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