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Technetium (99mTc) nofetumomab merpentan
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Technetium (99mTc) nofetumomab merpentan

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Technetium (99mTc) nofetumomab merpentan
Technetium-99m nofetumomab merpentan skeletal.svg
Monoclonal antibody
Type Fab fragment
Source Mouse
Clinical data
Trade names Verluma
ATC code
  • none
Pharmacokinetic data
Elimination half-life 10.5 hours
Excretion renal (64%)
Identifiers
CAS Number
ChemSpider
  • none
UNII
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Technetium (99mTc) nofetumomab merpentan (trade name Verluma) is a mouse monoclonal antibody derivative used in the diagnosis of lung cancer,gastrointestinal, breast, ovary, pancreas, kidney, cervix, and bladder carcinoma. The antibody part, nofetumomab, is attached to the chelator merpentan, which links it to the radioisotope technetium-99m (99mTc).

Nofetumomab

Nofetumomab is an antibody fragment that recognises the pancarcinoma glycoprotein antigen EpCAM. and/or CD20/MS4A1

It is the Fab part of murine MAb NR-LU-10.

Merpentan

The chelator part : merpentan is a phenthioate ligand, 2,3,5,6-tetrafluorophenyl-4,5-bis-5-[1-ethoxyethyl]-thioacetoamidopentanoate.

Phenthioate

Phenthioate is an insecticide (Cidial) = O,o-dimethyl-S-(carbethoxy-phenylmethyl)dithiophosphate


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