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Template:Comparison of early clinical experience with antiestrogens for advanced breast cancer
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Template:Comparison of early clinical experience with antiestrogens for advanced breast cancer
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Antiestrogen | Dosage | Year(s) | Response rate | Toxicity |
---|---|---|---|---|
Ethamoxytriphetol | 500–4,500 mg/day | 1960 | 25% | Acute psychotic episodes |
Clomifene | 100–300 mg/day | 1964–1974 | 34% | Fears of cataracts |
Nafoxidine | 180–240 mg/day | 1976 | 31% | Cataracts, ichthyosis, photophobia |
Tamoxifen | 20–40 mg/day | 1971–1973 | 31% | Transient thrombocytopeniaa |
Footnotes: a = "The particular advantage of this drug is the low incidence of troublesome side effects (25)." "Side effects were usually trivial (26)." Sources: |
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