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Template:Comparison of early clinical experience with antiestrogens for advanced breast cancer
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    Template:Comparison of early clinical experience with antiestrogens for advanced breast cancer

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    Comparison of early clinical experience with antiestrogens for advanced breast cancer
    Antiestrogen Dosage Year(s) Response rate Toxicity
    Ethamoxytriphetol 500–4,500 mg/day 1960 25% Acute psychotic episodes
    Clomifene 100–300 mg/day 1964–1974 34% Fears of cataracts
    Nafoxidine 180–240 mg/day 1976 31% Cataracts, ichthyosis, photophobia
    Tamoxifen 20–40 mg/day 1971–1973 31% Transient thrombocytopeniaa
    Footnotes: a = "The particular advantage of this drug is the low incidence of troublesome side effects (25)." "Side effects were usually trivial (26)." Sources:

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