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ThroLy score
Thrombosis Lymphoma (ThroLy) predictive score is a multivariable model for thromboembolic events in patients with lymphoma.
Characteristics
ThroLy score was developed and published in 2017 by a group of doctors from Serbia and United States. As a simple model, it was initially internally validated based on individual clinical and laboratory patient characteristics that would classify lymphoma patients at risk for a thromboembolic event. Based on the investigation conducted on derivation and validation cohorts, the variables independently associated with the risk for thromboembolism were: previous venous and/or arterial events, mediastinal involvement, BMI>30 kg/m2, reduced mobility, extranodal localization, development of neutropenia and hemoglobin level < 100g/L.
Patient characteristics | Assigned score |
---|---|
Previous venous thromboembolic event | 2 |
Reduced mobility | 1 |
Previous acute miocardial infarction or stroke | 2 |
Obesity (BMI ≥ 30) | 2 |
Extranodal localization | 1 |
Mediastinal involvement | 2 |
Neutropenia | 1 |
Hemoglobin˂100g/L | 1 |
Risk classification
Based on the risk score, patients with lymphoma can be classified in three different risk groups.
Risk group | ThroLy score |
---|---|
Low risk | 0-1 |
Intermediate risk | 2-3 |
High risk | ≥4 |
Further validations
ThroLy score considers some particular characteristics of lymphoma patients, such as extranodal localization and mediastinal involvement. In addition to having a strong positive predictive value, the score is not limited to either hospitalized or outpatient settings, and does not require non-routine laboratory analyses. In order to be fully applicable in clinical practice, several validation studies have been performed, and several more are ongoing.