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ThroLy score
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    ThroLy score

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    Thrombosis Lymphoma (ThroLy) predictive score is a multivariable model for thromboembolic events in patients with lymphoma.

    Characteristics

    ThroLy score was developed and published in 2017 by a group of doctors from Serbia and United States. As a simple model, it was initially internally validated based on individual clinical and laboratory patient characteristics that would classify lymphoma patients at risk for a thromboembolic event. Based on the investigation conducted on derivation and validation cohorts, the variables independently associated with the risk for thromboembolism were: previous venous and/or arterial events, mediastinal involvement, BMI>30 kg/m2, reduced mobility, extranodal localization, development of neutropenia and hemoglobin level < 100g/L.

    Patient characteristics Assigned score
    Previous venous thromboembolic event 2
    Reduced mobility 1
    Previous acute miocardial infarction or stroke 2
    Obesity (BMI ≥ 30) 2
    Extranodal localization 1
    Mediastinal involvement 2
    Neutropenia 1
    Hemoglobin˂100g/L 1

    Risk classification

    Based on the risk score, patients with lymphoma can be classified in three different risk groups.

    Risk group ThroLy score
    Low risk 0-1
    Intermediate risk 2-3
    High risk ≥4

    Further validations

    ThroLy score considers some particular characteristics of lymphoma patients, such as extranodal localization and mediastinal involvement. In addition to having a strong positive predictive value, the score is not limited to either hospitalized or outpatient settings, and does not require non-routine laboratory analyses. In order to be fully applicable in clinical practice, several validation studies have been performed, and several more are ongoing.


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